ArticleEBioMedicine2016
Advanced Circadian Phase in Mania and Delayed Circadian Phase in Mixed Mania and Depression Returned to Normal after Treatment of Bipolar Disorder.
Article in EBioMedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 4 syntheses or guidelines pooled it, 156 citations in OpenAlex.
- Melatonergic agents influence the sleep-wake and circadian rhythms in healthy and psychiatric participants: a systematic review and meta-analysis of randomized controlled trials.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Pooled it
- Hypnotic and Melatonin/Melatonin-Receptor Agonist Treatment in Bipolar Disorder: A Systematic Review and Meta-Analysis.CNS drugs · 2022Pooled it
- Toward a Digital Future in Bipolar Disorder Assessment: A Systematic Review of Disruptions in the Rest-Activity Cycle as Measured by Actigraphy.Frontiers in psychiatry · 2022Pooled it
- Face and predictive validity of the ClockΔ19 mouse as an animal model for bipolar disorder: a systematic review.Molecular psychiatry · 2018Pooled it
- The Ottawa sunglasses at night study: A randomized controlled trial of blue-blocking glasses for mania.Journal of affective disorders · 2026Trial
- The feasibility of conducting non-pharmacological research studies in participants with mania: a grounded theory qualitative analysis of the Ottawa Sunglasses at Night study.International journal of qualitative studies on health and well-being · 2025Trial
- Time-of-day variation in motivation for everyday behaviors: A cluster-based approach to understanding individual differences.iScience · 2026Article
- Identifying Mood Instability and Circadian Rest-Activity Patterns Using Digital Remote Monitoring and Actigraphy in Participants at Risk for Bipolar Disorder.Bipolar disorders · 2026Article
- Essential Information About Chronobiology and Chronotherapy for the Optimal Care of People With Bipolar Disorders: An Expert Consensus.Bipolar disorders · 2026Article
- The Role of Chronopsychiatry in Precision Medicine: Circadian Dysregulation as Diagnostic Marker and Therapeutic Target.Current sleep medicine reports · 2026Review
- Melatonin Circadian Phase Timing and Stability: Associations With Mood Symptoms Among a Clinically-Enriched Sample of Young Adults With Mood Disorders.Journal of pineal research · 2026Article
- Associations between chronotype and psychiatric symptoms across the adult lifespan.Translational psychiatry · 2025Article
- Moving toward precision and personalized treatment strategies in psychiatry.The international journal of neuropsychopharmacology · 2025Review
- Chronotherapeutic Treatments for Psychiatric Disorders: A Narrative Review of Recent Literature.Current psychiatry reports · 2025Review
- Circadian phase instability in bipolar disorder: a neglected essence.Trends in molecular medicine · 2025Review
- Managing Circadian Rhythms: A Key to Enhancing Mental Health in College Students.Psychiatry investigation · 2024Article
- Accurately predicting mood episodes in mood disorder patients using wearable sleep and circadian rhythm features.NPJ digital medicine · 2024Article
- Optimizing Chronotherapy in Psychiatric Care: The Impact of Circadian Rhythms on Medication Timing and Efficacy.Clocks & sleep · 2024Review
- Sleep and circadian disruption in bipolar disorders: From psychopathology to digital phenotyping in clinical practice.Psychiatry and clinical neurosciences · 2024Review
- NEK4 modulates circadian fluctuations of emotional behaviors and synaptogenesis in male mice.Nature communications · 2024Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Disturbances in circadian rhythms have been suggested as a possible cause of bipolar disorder (BD). Included in this study were 31 mood episodes of 26 BD patients, and 18 controls. Circadian rhythms of BD were evaluated at admission, at 2-week intervals during hospitalization, and at discharge. All participants wore wrist actigraphs during the studies. Saliva and buccal cells were obtained at 8:00, 11:00, 15:00, 19:00, and 23:00 for two consecutive days. Collected saliva and buccal cells were used for analysis of the cortisol and gene circadian rhythm, respectively. Circadian rhythms had different phases during acute mood episodes of BD compared to recovered states. In 23 acute manic episodes, circadian phases were ~7hour advanced (equivalent to ~17hour delayed). Phases of 21 out of these 23 cases returned to normal by ~7hour delay along with treatment, but two out of 23 cases returned to normal by ~17hour advance. In three cases of mixed manic episodes, the phases were ~6-7hour delayed. For five cases of depressive episodes, circadian rhythms phases were ~4-5hour delayed. After treatment, circadian phases resembled those of healthy controls. Circadian misalignment due to circadian rhythm phase shifts might be a pathophysiological mechanism of BD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.