ArticleGynecologic oncology2016
Is age a prognostic biomarker for survival among women with locally advanced cervical cancer treated with chemoradiation? An NRG Oncology/Gynecologic Oncology Group ancillary data analysis.
Article in Gynecologic oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Patient-reported outcomes at discontinuation of anti-angiogenesis therapy in the randomized trial of chemotherapy with bevacizumab for advanced cervical cancer: an NRG Oncology Group study.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2020Trial
- Pre-Treatment PET Radiomics for Prediction of Disease-Free Survival in Cervical Cancer.Cancers · 2025Article
- Article
- Monocentric Retrospective Study: Efficacy, Feasibility, and Prognostic Factors of Single-Insertion High-Dose-Rate Brachytherapy With 4 Sessions for Locally Advanced Cervical Cancer.Advances in radiation oncology · 2024Article
- Development and validation of aBMC cancer · 2024Article
- Therapeutic Approaches to Increase the Survival Rate of Cancer Patients in the Younger and Older Population.Current aging science · 2024Review
- Experiences of human papillomavirus self-sampling by women >60 years old: A qualitative study.Health expectations : an international journal of public participation in health care and health policy · 2023Article
- Outcomes and prognostic factors in patients with locally advanced cervical cancer treated with concurrent chemoradiotherapy.Radiation oncology (London, England) · 2022Article
- Prognostic factors for IB2-IIIB cervical cancer patients treated by radiation therapy with high-dose-rate brachytherapy in a single-institution study.Journal of contemporary brachytherapy · 2022Article
- Age as a potential predictor of acute side effects during chemoradiotherapy in primary cervical cancer patients.BMC cancer · 2022Article
- Combination of Radiomics and Machine Learning with Diffusion-Weighted MR Imaging for Clinical Outcome Prognostication in Cervical Cancer.Tomography (Ann Arbor, Mich.) · 2021Article
- Prognostic Nomogram for Overall Survival of Patients Aged 50 Years or Older with Cervical Cancer.International journal of general medicine · 2021Article
- Practical brachytherapy solutions to an age-old quandary.Technical innovations & patient support in radiation oncology · 2020Review
- Association of MRI-derived radiomic biomarker with disease-free survival in patients with early-stage cervical cancer.Theranostics · 2020Article
- Prognostic value of ADC quantification for clinical outcome in uterine cervical cancer treated with concurrent chemoradiotherapy.European radiology · 2019Article
- Value of blood oxygenation level-dependent MRI for predicting clinical outcomes in uterine cervical cancer treated with concurrent chemoradiotherapy.European radiology · 2019Article
- External validation of a combined PET and MRI radiomics model for prediction of recurrence in cervical cancer patients treated with chemoradiotherapy.European journal of nuclear medicine and molecular imaging · 2019Article
- Management for locally advanced cervical cancer: new trends and controversial issues.Radiation oncology journal · 2018Article
- Too many women are dying from cervix cancer: Problems and solutions.Gynecologic oncology · 2018Review
- Postoperative chemoradiotherapy versus radiotherapy alone for elderly cervical cancer patients with positive margins, lymph nodes, or parametrial invasion.Journal of gynecologic oncology · 2018Article
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Funding
Abstract
objectiveTo determine the effect of age on completion of and toxicities following treatment of local regionally advanced cervical cancer (LACC) on Gynecologic Oncology Group (GOG) Phase I-III trials.
methodsAn ancillary data analysis of GOG protocols 113, 120, 165, 219 data was performed. Wilcoxon, Pearson, and Kruskal-Wallis tests were used for univariate and multivariate analysis. Log rank tests were used to compare survival lengths.
resultsOne-thousand-three-hundred-nineteen women were included; 60.7% were Caucasian, 15% were age 60-70years and an additional 5% were >70; 87% had squamous histology, 55% had stage IIB disease and 34% had IIIB disease. Performance status declined with age (p=0.006). Histology and tumor stage did not significantly differ. Number of cycles of chemotherapy received, radiation treatment time, nor dose modifications varied with age. Notably, radiation protocol deviations and failure to complete brachytherapy (BT) did increase with age (p=0.022 and p<0.001 respectively). Only all grade lymphatic (p=0.006) and grade≥3 cardiovascular toxicities (p=0.019) were found to vary with age. A 2% increase in the risk of death for every year increase >50 for all-cause mortality (HR 1.02; 95% CI, 1.01-1.04) was found, but no association between age and disease specific mortality was found.
conclusionThis represents a large analysis of patients treated for LACC with chemo/radiation, approximately 20% of whom were >60years of age. Older patients, had higher rates of incomplete brachytherapy which is not explained by collected toxicity data. Age did not adversely impact completion of chemotherapy and radiation or toxicities.
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