Evidence map›Paper›PMID 27542852›Full record

ArticleNeurosurgical review2017

Biological relevance of tissue factor and IL-6 in arteriovenous malformations.

Shouhei Noshiro, Takeshi Mikami, Yuko Kataoka-Sasaki, Masanori Sasaki, Kazuo Hashi, Shunya Ohtaki, Masahiko Wanibuchi, Nobuhiro Mikuni, Jeffery D Kocsis, Osamu Honmou

Abstract read
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In one paragraph

Article in Neurosurgical review, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Shouhei NoshiroDepartment of Neurosurgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido, 060-8543, Japan.
Takeshi MikamiDepartment of Neurosurgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido, 060-8543, Japan. tmikami@sapmed.ac.jp.ORCID http://orcid.org/0000-0002-8608-1037
Yuko Kataoka-SasakiDepartment of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, 060-8543, Japan.
Masanori SasakiDepartment of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, 060-8543, Japan.
Kazuo HashiDepartment of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, 060-8543, Japan.
Shunya OhtakiDepartment of Neurosurgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido, 060-8543, Japan.
Masahiko WanibuchiDepartment of Neurosurgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido, 060-8543, Japan.
Nobuhiro MikuniDepartment of Neurosurgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido, 060-8543, Japan.
Jeffery D KocsisDepartment of Neurology, Yale University School of Medicine, New Haven, CT, 06510, USA.
Osamu HonmouDepartment of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, 060-8543, Japan.
Sapporo Medical University · JPYale University · US

Funding

Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes for Treatment of Contusive Spinal Cord InjuryI01BX003190 · VA · VA CONNECTICUT HEALTHCARE SYSTEM · PI KOCSIS, JEFFERY D. · 2017 to 2020
–
BLRD VA I01 BX003190
6 · The paper itself

Abstract

Arteriovenous malformations (AVMs) are congenital abnormal vessels that shunt blood directly from the arterial to the venous system without a capillary bed. The underlying pathology of AVMs is not fully understood. The objective of the study was to determine the association between the expression patterns of tissue factor (TF) and interleukin-6 (IL-6) in AVMs with clinical and pathological findings. Eighteen cases of sporadic AVM with operative specimens were included in this study. The expression of messenger RNA (mRNA) of TF and IL-6 was assayed, and association with clinical factors was investigated. The distribution of TF and IL-6 was examined with immunofluorescence. The mRNA expression of TF was significantly higher in AVM specimens than in control tissues (P = 0.002) and significantly higher in the symptomatic group than in the asymptomatic group (P = 0.037). The mRNA expression of IL-6 was likewise significantly higher in AVM specimens than in control tissues (P = 0.038). Examination of immunostained sections indicated that TF

Indexed as

AdolescentAdultBiomarkersCapillariesChildChild, PreschoolFemaleHumansInterleukin-6Intracranial Arteriovenous MalformationsMaleMiddle AgedPlatelet Endothelial Cell Adhesion Molecule-1RNA, MessengerThromboplastinVascular Endothelial Growth Factor Receptor-2BiomarkersIL6 protein, humanInterleukin-6KDR protein, humanPlatelet Endothelial Cell Adhesion Molecule-1RNA, MessengerThromboplastinVascular Endothelial Growth Factor Receptor-2Cerebral arteriovenous malformationsEndothelial cellInterleukin-6Tissue factor

Identifiers

PMID27542852
OpenAlexW2508354984

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.