Trial reportBMC family practice2016
Diagnostic accuracy of a pocket screening spirometer in diagnosing chronic obstructive pulmonary disease in general practice: a cross sectional validation study using tertiary care as a reference.
Trial report in BMC family practice, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01550679 (Early Detection of COPD Patients in GOLD 0), which is not on this map. Cited by 16 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Detection of COPD Patients in GOLD 0 (Smokers) Population
Who cites it
16 citing papers in PubMed, 5 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- How to Enhance the Diagnosis of Early Stages of Chronic Obstructive Pulmonary Disease (COPD)? The Role of Mobile Spirometry in COPD Screening and Diagnosis-A Systematic Review.Advances in respiratory medicine · 2024Pooled it
- Accuracy of portable spirometers in the diagnosis of chronic obstructive pulmonary disease A meta-analysis.NPJ primary care respiratory medicine · 2022Pooled it
- The Effectiveness and Harms of Screening for Chronic Obstructive Pulmonary Disease: An Updated Systematic Review and Meta-Analysis.Journal of Korean medical science · 2022Pooled it
- Performance of alternative COPD case-finding tools: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2021Pooled it
- Diagnostic performance of FEVChronic respiratory diseasePooled it
- Precision and accuracy of FEV1 measurements from the Vitalograph copd-6 mini-spirometer in a healthy Ugandan population.PloS one · 2021Trial
- Early Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease: The Costs and Benefits of Case Finding.American journal of respiratory and critical care medicine · 2024Article
- Article
- Current Progress of COPD Early Detection: Key Points and Novel Strategies.International journal of chronic obstructive pulmonary disease · 2023Review
- Different Case Finding Approaches to Optimise COPD Diagnosis: Evidence from the RADICALS Trial.International journal of chronic obstructive pulmonary disease · 2023Article
- Accuracy and economic evaluation of screening tests for undiagnosed COPD among hypertensive individuals in Brazil.NPJ primary care respiratory medicine · 2022Article
- Article
- Article
- Medical devices in allergy practice.The World Allergy Organization journal · 2020Review
- Accuracy of Vitalograph lung monitor as a screening test for COPD in primary care.NPJ primary care respiratory medicine · 2020Article
- Early detection of COPD patients in GOLD 0 population: an observational non-interventional cohort study - MARKO study.BMC pulmonary medicine · 2017Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCOPD-6™ is a lung function testing device for a rapid pre-spirometry testing to screen-out at-risk individuals not having COPD and indicating those at risk. The aim of this study was to validate COPD-6™ lung function testing (index test) in general practice in discriminating patients with COPD out of the population at risk - smokers/ex-smokers with no previous diagnosis of COPD, using measurements at tertiary care as reference standard.
methodsConsecutive 227 subjects (115 women, 185 smokers/42 ex-smokers, ≥20 pack-years) with no previous diagnosis of COPD, aged 52.5 (SD 6.8) years from 26 general practitioners (GPs) were recruited, lung function tested with COPD-6™, referred to the tertiary institution for repeated COPD-6™ testing followed by spirometry with a bronchodilator (salbutamol), examination, and pulmonologist consultation for the diagnosis and severity of COPD.
resultsCOPD was diagnosed in 43 subjects (18.9 %), with an AUC of 0.827 (95 % CI 0.769-0.875, P < 0.001) for the diagnosis of COPD when lung function was measured using COPD-6™ in GP's office with a specificity of 100 % (95 % CI, 97.95-100 %) but a very low sensitivity of 32.56 % (95 % CI, 20.49-47.48 %). Significant agreement for forced expiratory volume in 1 s measured at GP's office and at lung function lab was found (mean difference 0.01 L, p = 0.667) but not for other measured parameters (p < 0.001 for all).
conclusionsOur study results point out that active case finding in a population at risk for COPD should be instituted (almost 20 % of undiagnosed COPD). Based on our results lung function testing with COPD-6™ can substitute spirometry testing in cases where it is not readily available to the patient/physician taken into account that the traditional FEV1/FEV6 cutoff value of <0.7 is not the only criterion for diagnosis and/or further referral.
trial registrationClinicalTrials.gov Identifier NCT01550679 Registered 28 September 2014, retrospectively registered.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.