Evidence map›Paper›PMID 27542008›Full record

ReviewJournal of cardiovascular translational research2016

Stem Cell Therapy for the Heart: Blind Alley or Magic Bullet?

Arne A N Bruyneel, Apurv Sehgal, Sophia Malandraki-Miller, Carolyn Carr

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cardiovascular translational research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Acquired Resilience: An Evolved System of Tissue Protection in Mammals.Dose-response : a publication of International Hormesis Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Arne A N BruyneelDepartment of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, UK.
Apurv SehgalUniversity of Oxford Medical School, Oxford, UK.
Sophia Malandraki-MillerDepartment of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, UK.
Carolyn CarrDepartment of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, UK. carolyn.carr@dpag.ox.ac.uk.ORCID 0000-0003-0102-5261
University of Oxford · GB

Funding

British Heart Foundation PG/13/34/30216
6 · The paper itself

Abstract

When stressed by ageing or disease, the adult human heart is unable to regenerate, leading to scarring and hypertrophy and eventually heart failure. As a result, stem cell therapy has been proposed as an ultimate therapeutic strategy, as stem cells could limit adverse remodelling and give rise to new cardiomyocytes and vasculature. Unfortunately, the results from clinical trials to date have been largely disappointing. In this review, we discuss the current status of the field and describe various limitations and how future work may attempt to resolve these to make way to successful clinical translation.

Indexed as

RegenerationStem Cell TransplantationAnimalsCell DifferentiationCell ProliferationCell SurvivalClinical Trials as TopicHeart DiseasesHumansMyocytes, CardiacPhenotypeRecovery of FunctionRegenerative MedicineSignal TransductionTranslational Research, BiomedicalCardiac stem cellsHeart diseaseRegenerative medicineStem cell therapy

Identifiers

PMID27542008
PMCPMC5153828
OpenAlexW2517099375

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.