ArticlePLoS computational biology2016
Inverse Stochastic Resonance in Cerebellar Purkinje Cells.
Article in PLoS computational biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Cerebellar microcircuits enable robust evidence-based decisions through cortico-cerebellar coupling.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- In vivo neural activity of electrosensory pyramidal cells: Biophysical characterization and phenomenological modeling.PLoS computational biology · 2025Article
- Purkinje cell models: past, present and future.Frontiers in computational neuroscience · 2024Review
- [The inverse stochastic resonance in a small-world neuronal network under electromagnetic stimulation].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2023Article
- Bistability at the onset of neuronal oscillations.Biological cybernetics · 2023Article
- Article
- Effects of chaotic activity and time delay on signal transmission in FitzHugh-Nagumo neuronal system.Cognitive neurodynamics · 2022Article
- Dynamics and Information Import in Recurrent Neural Networks.Frontiers in computational neuroscience · 2022Article
- Noise induced quiescence of epileptic spike generation in patients with epilepsy.Journal of computational neuroscience · 2021Article
- Progressive alignment of inhibitory and excitatory delay may drive a rapid developmental switch in cortical network dynamics.Journal of neurophysiology · 2020Article
- Proprioceptive Focal Stimulation (Equistasi®) May Improve the Quality of Gait in Middle-Moderate Parkinson's Disease Patients. Double-Blind, Double-Dummy, Randomized, Crossover, Italian Multicentric Study.Frontiers in neurology · 2019Article
- Complex Electroresponsive Dynamics in Olivocerebellar Neurons Represented With Extended-Generalized Leaky Integrate and Fire Models.Frontiers in computational neuroscience · 2019Article
- Weak-noise-induced transitions with inhibition and modulation of neural oscillations.Biological cybernetics · 2018Article
- On the complex dynamics of savanna landscapes.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Inverse stochastic resonance in networks of spiking neurons.PLoS computational biology · 2017Article
- Movement Rate Is Encoded and Influenced by Widespread, Coherent Activity of Cerebellar Molecular Layer Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Modulation of neuronal dynamic range using two different adaptation mechanisms.Neural regeneration research · 2017Article
- Article
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5 authors.
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Abstract
Purkinje neurons play an important role in cerebellar computation since their axons are the only projection from the cerebellar cortex to deeper cerebellar structures. They have complex internal dynamics, which allow them to fire spontaneously, display bistability, and also to be involved in network phenomena such as high frequency oscillations and travelling waves. Purkinje cells exhibit type II excitability, which can be revealed by a discontinuity in their f-I curves. We show that this excitability mechanism allows Purkinje cells to be efficiently inhibited by noise of a particular variance, a phenomenon known as inverse stochastic resonance (ISR). While ISR has been described in theoretical models of single neurons, here we provide the first experimental evidence for this effect. We find that an adaptive exponential integrate-and-fire model fitted to the basic Purkinje cell characteristics using a modified dynamic IV method displays ISR and bistability between the resting state and a repetitive activity limit cycle. ISR allows the Purkinje cell to operate in different functional regimes: the all-or-none toggle or the linear filter mode, depending on the variance of the synaptic input. We propose that synaptic noise allows Purkinje cells to quickly switch between these functional regimes. Using mutual information analysis, we demonstrate that ISR can lead to a locally optimal information transfer between the input and output spike train of the Purkinje cell. These results provide the first experimental evidence for ISR and suggest a functional role for ISR in cerebellar information processing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.