ArticleWorld journal of urology2017
MRI-guided focal laser ablation for prostate cancer followed by radical prostatectomy: correlation of treatment effects with imaging.
Article in World journal of urology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 49 citations in OpenAlex.
- Percutaneous laser ablation: a new contribution to unresectable high-risk metastatic retroperitoneal lesions?Oncotarget · 2017Trial
- A Detailed Clinical Case of Localized Prostate Tumors Treated with Nanoparticle-Assisted Sub-Ablative Laser Ablation.Nanomaterials (Basel, Switzerland) · 2024Article
- Evolution of non-perfused volume after transurethral ultrasound ablation of prostate: A retrospective 12-month analysis.European journal of radiology open · 2023Article
- Reliable Visualization of the Treatment Effect of Transperineal Focal Laser Ablation in Prostate Cancer Patients by Magnetic Resonance Imaging and Contrast-enhanced Ultrasound Imaging.European urology open science · 2023Article
- Narrative review-focal therapy: are we ready to change the prostate cancer treatment paradigm?Annals of translational medicine · 2023Review
- Interstitial Optical Monitoring of Focal Laser Ablation.IEEE transactions on bio-medical engineering · 2022Article
- Safety and Feasibility of Soractelite Transperineal Focal Laser Ablation for Prostate Cancer and Short-term Quality of Life Analysis from a Multicenter Pilot Study.European urology open science · 2022Article
- MR Imaging in Real Time Guiding of Therapies in Prostate Cancer.Life (Basel, Switzerland) · 2022Review
- Prospective trial of regional (hockey-stick) prostate cryoablation: oncologic and quality of life outcomes.World journal of urology · 2021Article
- Defining prostate cancer size and treatment margin for focal therapy: does intralesional heterogeneity impact the performance of multiparametric MRI?BJU international · 2021Article
- Interventional therapy in malignant conditions of the prostate.Der Radiologe · 2019Review
- Utility of Multiparametric MRI for Predicting Residual Clinically Significant Prostate Cancer After Focal Laser Ablation.AJR. American journal of roentgenology · 2019Observational
- Temporal changes in MRI appearance of the prostate after focal ablation.Abdominal radiology (New York) · 2019Article
- A tissue-mimicking prostate phantom for 980 nm laser interstitial thermal therapy.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2019Article
- Optimizing patient selection for focal therapy-mapping and ablating the index lesion.Translational andrology and urology · 2018Article
- Validation of the current eligibility criteria for focal therapy in men with localized prostate cancer and the role of MRI.World journal of urology · 2018Article
- Accuracy of tumor segmentation from multi-parametric prostate MRI andEJNMMI research · 2018Article
- Multimodal Imaging in Focal Therapy Planning and Assessment in Primary Prostate Cancer.Clinical and translational imaging · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo correlate treatment effects of MRI-guided focal laser ablation in patients with prostate cancer with imaging using prostatectomy as standard of reference.
methodsThis phase I study was approved by the Institutional Review Board. Three weeks prior to prostatectomy, five patients with histopathologically proven, low/intermediate grade prostate cancer underwent transrectal MRI-guided focal laser ablation. Per patient, only one ablation was performed to investigate the effect of ablation on the tissue rather than the effectiveness of ablation. Ablation was continuously monitored with real-time MR temperature mapping, and damage-estimation maps were computed. A post-ablation high-resolution T1-weighted contrast-enhanced sequence was acquired. Ablation volumes were contoured and measured on histopathology specimens (with a shrinkage factor of 1.15), T1-weighted contrast-enhanced images, and damage-estimation maps, and were compared.
resultsA significant volume correlation was seen between the ablation zone on T1-weighted contrast-enhanced images and the whole-mount histopathology section (r = 0.94, p = 0.018). The damage-estimation maps and histopathology specimen showed a correlation of r = 0.33 (p = 0.583). On histopathology, the homogeneous necrotic area was surrounded by a reactive transition zone (1-5 mm) zone, showing neovascularisation, and an increased mitotic index, indicating increased tumor activity.
conclusionsThe actual ablation zone was better indicated by T1-weighted contrast-enhanced than by damage-estimation maps. Histopathology results highlight the importance of complete tumor ablation with a safety margin.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.