Evidence map›Paper›PMID 27541550›Full record

SynthesisOncology nursing forum2016

The Association Between Patient-Reported and Objective Oral Anticancer Medication Adherence Measures: A Systematic Review
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Thomas M Atkinson, Vivian M Rodríguez, Mallorie Gordon, Isabelle K Avildsen, Jessica C Emanu, Sarah T Jewell, Kimberly A Anselmi, Pamela K Ginex

Abstract readComparative StudySystematic Review
In one paragraph

Synthesis in Oncology nursing forum, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
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  7. Article
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  9. Review
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  14. Challenges to the design and testing supportive interventions for cancer patients treated with oral oncolytic agents.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Thomas M AtkinsonMemorial Sloan Kettering Cancer Center.
Vivian M RodríguezMemorial Sloan Kettering Cancer Center.
Mallorie GordonMemorial Sloan Kettering Cancer Center.
Isabelle K AvildsenMemorial Sloan Kettering Cancer Center.
Jessica C EmanuMemorial Sloan Kettering Cancer Center.
Sarah T JewellRutgers University.
Kimberly A AnselmiMemorial Sloan Kettering Cancer Center.
Pamela K GinexMemorial Sloan Kettering Cancer Center.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Psychosocial Palliative & Community Research in CancerT32CA009461 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI JENNIFER L HAY, Jamie S. Ostroff · 1985 to 2026
$10.1M
NCI NIH HHS P30 CA008748NCI NIH HHS T32 CA009461
6 · The paper itself

Abstract

problem identificationOral anticancer medication (OAM) use has been steadily increasing, leading to several patient benefits. A notable challenge for nurses is accurate monitoring of patient OAM regimens because nonadherence is associated with poor health outcomes and decreased survival. Currently, no gold standard measure of OAM adherence exists. The authors conducted a systematic review of the association between objective and patient-reported measures of OAM adherence.
. LITERATURE SEARCH: A systematic electronic literature search was conducted using PubMed, EMBASE, Scopus, PsycINFO®, Cochrane Library, Web of Science, and CINAHL® databases through November 2014. 
. DATA EVALUATION: Articles were independently reviewed to determine whether they included an original characterization of the level of association between objective and patient-reported measures of OAM adherence.
. SYNTHESIS: From a total of 11,135 articles retrieved, eight studies met inclusion criteria. Objective adherence was primarily assessed using pill counts or Medication Event Monitoring System (MEMSCap™). Patient-reported adherence was most commonly assessed using study-specific questionnaires. Significant positive correlations were observed between objective and patient-reported adherence across most studies, with three studies reporting higher rates of adherence via patient reporting.
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conclusionsDespite variation in the OAMs and measures used, patient-reported adherence rates were equal to or higher than objective adherence measures across studies. Social desirability bias may be a concern; however, given the significant concordance observed, using patient-reported methods in future studies of OAM adherence may be justified. 
. IMPLICATIONS FOR NURSING: This review provides evidence to support nursing use of patient-reported measures to accurately monitor OAM adherence and potentially improve the quality of patient-provider communication.

Indexed as

Drug MonitoringSelf ReportAdministration, OralAdultAgedAged, 80 and overAntineoplastic AgentsFemaleHumansMaleMedication AdherenceMiddle AgedNeoplasmsSurveys and QuestionnairesAntineoplastic Agentsmedication adherenceneoplasmsoral medicinepatient outcome assessment

Identifiers

PMID27541550
PMCPMC5008846

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.