ArticleJournal of neuroimaging : official journal of the American Society of Neuroimaging2017
Limbic Pathway Correlates of Cognitive Impairment in Multiple Sclerosis.
Article in Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Moderating effects of limbic white matter on verbal memory in older adults with multiple sclerosis.Neuropsychology · 2026Article
- White matter microstructure abnormalities in thalassemia patients using TBSS analysis based on DTI.Scientific reports · 2025Article
- AI-driven MRI analysis reveals brain atrophy patterns in benign relapsing-remitting multiple sclerosis.Frontiers in neurology · 2025Article
- Cognitive impairment in multiple sclerosis: from phenomenology to neurobiological mechanisms.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Limbic pathway vulnerability associates with neurologic outcome in children after cardiac arrest.Resuscitation · 2023Article
- Analysis of the extent of limbic system changes in multiple sclerosis using FreeSurfer and voxel-based morphometry approaches.PloS one · 2022Article
- Frontal aslant tracts as correlates of lexical retrieval in MS.Neurological research · 2020Article
- Diffusion tensor imaging tractography reveals altered fornix in all diagnostic subtypes of multiple sclerosis.Brain and behavior · 2020Article
- Voxel-based analysis of gray matter relaxation rates shows different correlation patterns for cognitive impairment and physical disability in relapsing-remitting multiple sclerosis.NeuroImage. Clinical · 2020Article
- Robustness of Brain Structural Networks Is Affected in Cognitively Impaired MS Patients.Frontiers in neurology · 2020Article
- Yakovlev's Basolateral Limbic Circuit in Multiple Sclerosis Related Cognitive Impairment.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2018Article
- Fractional anisotropy of white matter, disability and blood iron parameters in multiple sclerosis.Metabolic brain disease · 2018Article
- Quantitative Limbic System Mapping of Main Cognitive Domains in Multiple Sclerosis.Frontiers in neurology · 2018Article
- The Role of Advanced Magnetic Resonance Imaging Techniques in Multiple Sclerosis Clinical Trials.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017Review
- Correlation between white matter damage and gray matter lesions in multiple sclerosis patients.Neural regeneration research · 2017Article
- Article
- High-resolution fluid-suppressed diffusion tractography of the fornix across the healthy lifespan and deviations in multiple sclerosis.Imaging neuroscience (Cambridge, Mass.)Article
- Disproportional smaller fornix with altered microstructure in pediatric multiple sclerosis shown by high-resolution fluid-suppressed diffusion tractography.Multiple sclerosis journal - experimental, translational and clinicalArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
background and purposeDistinct injuries to various limbic white matter pathways have been reported to be associated with different aspects of cognitive dysfunction in multiple sclerosis (MS). Diffusion tensor imaging (DTI) offers a noninvasive method to map tissue microstructural organization. We utilized quantitative magnetic resonance imaging methods to analyze the main limbic system-white matter structures in MS patients with cognitive impairment (CI).
methodsTen cognitively nonimpaired MS (MSNI) patients and 36 patients with diagnosed CI (MSCI) underwent the minimal assessment of Cognitive Function in MS (MACFIMS) battery. DTI measures of fornix, cingulum, uncinate fasciculus (UF) included tract volume and corresponding fractional anisotropy (FA), mean (MD), axial (AD), and radial (AD) diffusivities. These were statistically analyzed for associations with CI after adjusting for the confounders.
resultsFornix FA and RD, left cingulum FA, MD, and RD, right cingulum FA, MD, and RD, and left UF FA showed significant differences between MSNI and MSCI (P < .001). Fornix FA (r = -.6) and RD (r = .52), and right cingulum FA (r = -.54) and RD (r = .5) correlated significantly with CI in regression analyses.
conclusionsThe extent of disruption of microstructural disorganization in the main limbic pathways using DTI impacts the extent of CI seen in subjects with MS.
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