Evidence map›Paper›PMID 27541354›Full record

Observational studyEuropean radiology2017

The effect of blood pressure on non-invasive fractional flow reserve derived from coronary computed tomography angiography.

Akira Kurata, Adriaan Coenen, Marisa M Lubbers, Koen Nieman, Teruhito Kido, Tomoyuki Kido, Natsumi Yamashita, Kouki Watanabe, Gabriel P Krestin, Teruhito Mochizuki

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Akira KurataDepartment of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan. akuratasan2000@gmail.com.
Adriaan CoenenDepartment of Radiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Marisa M LubbersDepartment of Radiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Koen NiemanDepartment of Radiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Teruhito KidoDepartment of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan.
Tomoyuki KidoDepartment of Radiology, Matsuyama Saiseikai Hospital, Matsuyama, Ehime, Japan.
Natsumi YamashitaDivision of Clinical Biostatistics, Section of Cancer Prevention and Epidemiology, Clinical Research Center, National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime, Japan.
Kouki WatanabeDepartment of Cardiology, Matsuyama Saiseikai Hospital, Matsuyama, Ehime, Japan.
Gabriel P KrestinDepartment of Radiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Teruhito MochizukiDepartment of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this study is to assess the effect of blood pressure (BP) on coronary computed tomography angiography (CTA) derived computational fractional flow reserve (CTA-FFR). MATERIALS AND

methodsTwenty-one patients who underwent coronary CTA and invasive FFR were retrospectively identified. Ischemia was defined as invasive FFR ≤0.80. Using a work-in-progress computational fluid dynamics algorithm, CTA-FFR was computed with BP measured before CTA, and simulated BPs of 60/50, 90/60, 110/70, 130/80, 150/90, and 180/100 mmHg respectively. Correlation between CTA-FFR and invasive FFR was assessed using Pearson test. The repeated measuring test was used for multiple comparisons of CTA-FFR values by simulated BP inputs.

resultsTwenty-nine vessels (14 with invasive FFR ≤0.80) were assessed. The average CTA-FFR for measured BP (134 ± 20/73 ± 12 mmHg) was 0.77 ± 0.12. Correlation between CTA-FFR by measured BP and invasive FFR was good (r = 0.735, P < 0.001). For simulated BPs of 60/50, 90/60, 110/70, 130/80, 150/90, and 180/100 mmHg, the CTA-FFR increased: 0.69 ± 0.13, 0.73 ± 0.12, 0.75 ± 0.12, 0.77 ± 0.11, 0.79 ± 0.11, and 0.81 ± 0.10 respectively (P < 0.05).

conclusionMeasurement of the BP just before CTA is preferred for accurate CTA-FFR simulation. BP variations in the common range slightly affect CTA-FFR. However, inaccurate BP assumptions differing from the patient-specific BP could cause misinterpretation of borderline significant lesions. KEY POINTS: • The blood pressure (BP) affects the CTA-FFR computation. • Measured BP before CT examination is preferable for accurate CTA-FFR simulation. • Inaccurate BP assumptions can cause misinterpretation of borderline significant lesions.

Indexed as

AgedAlgorithmsBlood PressureComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseFemaleFractional Flow Reserve, MyocardialHumansMaleRetrospective StudiesSeverity of Illness IndexBlood pressureComputed tomographyCoronary artery diseaseFractional flow reserveMyocardial ischemia

Identifiers

PMID27541354

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.