Evidence map›Paper›PMID 27540855›Full record

ReviewMolecular cell2016

Diverse Activities of Histone Acylations Connect Metabolism to Chromatin Function.

Arnob Dutta, Susan M Abmayr, Jerry L Workman

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 83 citations in OpenAlex.

  1. Review
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  5. Biochemistry and regulation of histone lysine L-lactylation.Nature reviews. Molecular cell biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Arnob DuttaStowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA.
Susan M AbmayrStowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA; Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Jerry L WorkmanStowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA. Electronic address: jlw@stowers.org.
Stowers Institute for Medical Research · USUniversity of Kansas Medical Center · US

Funding

Transcription regulation in chromatinR35GM118068 · NIGMS · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI JERRY L WORKMAN · 2016 to 2026
$4.2M
NIGMS NIH HHS R35 GM118068
6 · The paper itself

Abstract

Modifications of histones play important roles in balancing transcriptional output. The discovery of acyl marks, besides histone acetylation, has added to the functional diversity of histone modifications. Since all modifications use metabolic intermediates as substrates for chromatin-modifying enzymes, the prevalent landscape of histone modifications in any cell type is a snapshot of its metabolic status. Here, we review some of the current findings of how differential use of histone acylations regulates gene expression as response to metabolic changes and differentiation programs.

Indexed as

Chromatin Assembly and DisassemblyEnergy MetabolismProtein Processing, Post-TranslationalAcylationAnimalsHistonesHumansSignal TransductionTranscription, GeneticHistonesbromodomainhistone acylationmetabolismYEATS domain

Identifiers

PMID27540855
PMCPMC5298895
OpenAlexW2516110596

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.