Evidence map›Paper›PMID 27540721›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2016

Pulse oximetry could significantly enhance the early detection of critical congenital heart disease in neonatal intensive care units.

Xiao-Jing Hu, Qu-Ming Zhao, Xiao-Jing Ma, Wei-Li Yan, Xiao-Ling Ge, Bing Jia, Fang Liu, Lin Wu, Ming Ye, Guo-Ying Huang

Open access · hybridAbstract readComparative Study
In one paragraph

Article in Acta paediatrica (Oslo, Norway : 1992), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. [Clinical value of AI-assisted cardiac auscultation in screening for congenital heart disease in neonates].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Evaluation of critical congenital heart defects screening using pulse oximetry in the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2017
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xiao-Jing HuPediatric Heart Center, Children's Hospital of Fudan University, Shanghai, China.
Qu-Ming ZhaoPediatric Heart Center, Children's Hospital of Fudan University, Shanghai, China.
Xiao-Jing MaPediatric Heart Center, Children's Hospital of Fudan University, Shanghai, China.
Wei-Li YanPediatric Heart Center, Children's Hospital of Fudan University, Shanghai, China.
Xiao-Ling GePediatric Heart Center, Children's Hospital of Fudan University, Shanghai, China.
Bing JiaPediatric Heart Center, Children's Hospital of Fudan University, Shanghai, China.
Fang LiuPediatric Heart Center, Children's Hospital of Fudan University, Shanghai, China.
Lin WuPediatric Heart Center, Children's Hospital of Fudan University, Shanghai, China.
Ming YePediatric Heart Center, Children's Hospital of Fudan University, Shanghai, China.
Guo-Ying HuangPediatric Heart Center, Children's Hospital of Fudan University, Shanghai, China. gyhuang@shmu.edu.cn.
Children's Hospital of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimLimited data have been available regarding critical congenital heart disease (CHD) screening in neonatal intensive care unit (NICUs). This study evaluated the feasibility of screening for CHD by adding pulse oximetry (POX) to clinical evaluation in a NICU in Shanghai, China.

methodsWe screened 4128 eligible consecutive NICU admissions using POX plus clinical evaluation. Infants with positive screening results were then evaluated with echocardiography. Those with negative screening results were put under observation, and they also underwent echocardiography if their oxygen saturation fell below 95% on room air during hospitalisation.

resultsThis enhanced procedure detected 19 critical CHD cases, and seven of these diagnoses would have been delayed if POX had not been incorporated into the screening strategy. This means that the addition of POX increased the detection rate of critical CHD from 63.2 to 100%. The false-positive rate of critical CHD screening using POX plus clinical evaluation was higher in NICU patients with high morbidity rates.

conclusionWhen pulse oximetry screening was added to clinical evaluation, it increased the number of critical CHD cases that were detected in our NICU. This method could provide a useful screening protocol for critical CHD cases.

Indexed as

ChinaEarly DiagnosisEchocardiographyFeasibility StudiesFemaleHeart Defects, CongenitalHumansInfant, NewbornIntensive Care Units, NeonatalMaleNeonatal ScreeningOutcome and Process Assessment, Health CareOximetrySensitivity and SpecificityClinical evaluationCongenital heart diseaseNeonatal intensive care unitNeonatal screeningPulse oximetry

Identifiers

PMID27540721
PMCPMC5095792
OpenAlexW2508725070

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.