ArticleACS applied materials & interfaces2016
PEGylated Artificial Antibodies: Plasmonic Biosensors with Improved Selectivity.
Article in ACS applied materials & interfaces, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 41 citations in OpenAlex.
- Interplay of Genotype and Substrate Stiffness in Driving the Hypertrophic Cardiomyopathy Phenotype in iPSC-Micro-Heart Muscle Arrays.Cellular and molecular bioengineering · 2021Article
- Molecularly Imprinted Polyscopoletin for the Electrochemical Detection of the Chronic Disease Marker Lysozyme.Biosensors · 2020Article
- Advances in Biomimetic Systems for Molecular Recognition and Biosensing.Biomimetics (Basel, Switzerland) · 2020Review
- Refreshable Nanobiosensor Based on Organosilica Encapsulation of Biorecognition Elements.ACS applied materials & interfaces · 2020Article
- Bioplasmonic paper-based assay for perilipin-2 non-invasively detects renal cancer.Kidney international · 2019Article
- PEGylation of protein-imprinted nanocomposites sandwiching CdTe quantum dots with enhanced fluorescence sensing selectivity.RSC advances · 2019Article
- Label-Free Detection of Tear Biomarkers Using Hydrogel-Coated Gold Nanoshells in a Localized Surface Plasmon Resonance-Based Biosensor.ACS nano · 2018Article
- Molecular Fingerprints of Hemoglobin on a Nanofilm Chip.Sensors (Basel, Switzerland) · 2018Article
- Environmental Stability of Plasmonic Biosensors Based on Natural versus Artificial Antibody.Analytical chemistry · 2018Article
- Improvement of a rapid diagnostic application of monoclonal antibodies against avian influenza H7 subtype virus using Europium nanoparticles.Scientific reports · 2017Article
- Single Molecule Force Spectroscopy to Compare Natural versus Artificial Antibody-Antigen Interaction.Small (Weinheim an der Bergstrasse, Germany) · 2017Article
- Aromatic Functionality of Target Proteins Influences Monomer Selection for Creating Artificial Antibodies on Plasmonic Biosensors.ACS applied materials & interfaces · 2017Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Molecular imprinting, which involves the formation of artificial recognition elements or cavities with complementary shape and chemical functionality to the target species, is a powerful method to overcome a number of limitations associated with natural antibodies. An important but often overlooked consideration in the design of artificial biorecognition elements based on molecular imprinting is the nonspecific binding of interfering species to noncavity regions of the imprinted polymer. Here, we demonstrate a universal method, namely, PEGylation of the noncavity regions of the imprinted polymer, to minimize the nonspecific binding and significantly enhance the selectivity of the molecular imprinted polymer for the target biomolecules. The nonspecific binding, as quantified by the localized surface plasmon resonance shift of imprinted plasmonic nanorattles upon exposure to common interfering proteins, was found to be more than 10 times lower compared to the non-PEGylated counterparts. The method demonstrated here can be broadly applied to a wide variety of functional monomers employed for molecular imprinting. The significantly higher selectivity of PEGylated molecular imprints takes biosensors based on these artificial biorecognition elements closer to real-world applications.
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