Evidence map›Paper›PMID 27540460›Full record

ArticleChemical science2016

Mechanistic Studies and Radiofluorination of Structurally Diverse Pharmaceuticals with Spirocyclic Iodonium(III) Ylides.

Benjamin H Rotstein, Lu Wang, Richard Y Liu, Jon Patteson, Eugene E Kwan, Neil Vasdev, Steven H Liang

Abstract read
In one paragraph

Article in Chemical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. [European journal of nuclear medicine and molecular imaging · 2023
    Trial
  2. Article
  3. Article
  4. Review
  5. Triflyl [Chemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  6. Performing [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  7. SyntheticRSC medicinal chemistry · 2024
    Review
  8. Article
  9. On the Risk ofOrganic letters · 2023
    Article
  10. Review
  11. [European journal of nuclear medicine and molecular imaging · 2023
    Article
  12. Article
  13. Review
  14. Radiochemical Synthesis of 4-[Molecules (Basel, Switzerland) · 2022
    Article
  15. Article
  16. Isotopic Radiolabeling of the Antiretroviral Drug [Pharmaceuticals (Basel, Switzerland) · 2022
    Article
  17. Easily automated radiosynthesis of [Frontiers in bioengineering and biotechnology · 2022
    Article
  18. Review
  19. Article
  20. The Journal of organic chemistry · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Benjamin H RotsteinDivision of Nuclear Medicine and Molecular Imaging & Gordon Center for Medical Imaging, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts, 02114, United States of America; Department of Radiology, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts, 02114, United States of America.
Lu WangDivision of Nuclear Medicine and Molecular Imaging & Gordon Center for Medical Imaging, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts, 02114, United States of America.
Richard Y LiuDepartment of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA, 02138, United States of America.
Jon PattesonDivision of Nuclear Medicine and Molecular Imaging & Gordon Center for Medical Imaging, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts, 02114, United States of America.
Eugene E KwanDepartment of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA, 02138, United States of America.
Neil VasdevDivision of Nuclear Medicine and Molecular Imaging & Gordon Center for Medical Imaging, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts, 02114, United States of America; Department of Radiology, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts, 02114, United States of America.
Steven H LiangDivision of Nuclear Medicine and Molecular Imaging & Gordon Center for Medical Imaging, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts, 02114, United States of America; Department of Radiology, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts, 02114, United States of America.

Funding

New PET tracers for neuroimaging of FAAH in endocannabinoid signalingK01DA038000 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI LIANG, STEVEN H · 2014 to 2018
$927k
NIDA NIH HHS K01 DA038000
6 · The paper itself

Abstract

Synthesis of non-activated electron-rich and sterically hindered

Identifiers

PMID27540460
PMCPMC4987086

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.