ArticleFrontiers in behavioral neuroscience2016
Mouse Social Network Dynamics and Community Structure are Associated with Plasticity-Related Brain Gene Expression.
Article in Frontiers in behavioral neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- A systematic review and meta-analysis of how social memory is studied.Scientific reports · 2024Pooled it
- A Systematic Review and Meta-Analysis of the Relationship Between Social Dominance Status and Common Behavioral Phenotypes in Male Laboratory Mice.Frontiers in behavioral neuroscience · 2020Pooled it
- Single-Nucleus Transcriptomics of the Mouse Medial Preoptic Area Reveals Sex-Dependent Molecular Signatures of Social Dominance.bioRxiv : the preprint server for biology · 2026Article
- Neural Bases of Collective Social Behavior and Group Interactions across Species.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Rapid Changes in Cholinergic Signaling, Myelination, and Thyroid Signaling Pathway Gene Expression in Amygdala Subnuclei in Response to Social Status Maintenance and Reorganization.The European journal of neuroscience · 2025Article
- Modeling collective behavior in groups of mice housed under semi-naturalistic conditions.eLife · 2025Article
- Information sharing within a social network is key to behavioral flexibility-Lessons from mice tested under seminaturalistic conditions.Science advances · 2025Article
- Article
- Luck, skill, and depth of competition in games and social hierarchies.Science advances · 2024Article
- Mice integrate conspecific and contextual information in forming social episodic-like memories under spontaneous recognition task conditions.Scientific reports · 2024Article
- The human neuropsychiatric risk gene Drd2 is necessary for social functioning across evolutionary distant species.Molecular psychiatry · 2024Article
- Re-wilding model organisms: Opportunities to test causal mechanisms in social determinants of health and aging.Neuroscience and biobehavioral reviews · 2023Review
- A paradigm shift in translational psychiatry through rodent neuroethology.Molecular psychiatry · 2023Review
- Social deficits in BTBR T+ Itpr3tf/J mice vary with ecological validity of the test.Genes, brain, and behavior · 2022Article
- Manifestations of domination: Assessments of social dominance in rodents.Genes, brain, and behavior · 2022Review
- DomArchive: a century of published dominance data.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Using social rank as the lens to focus on the neural circuitry driving stress coping styles.Current opinion in neurobiology · 2021Review
- Effect of relative social rank within a social hierarchy on neural activation in response to familiar or unfamiliar social signals.Scientific reports · 2021Article
- Who's the Boss? Assessing Convergent Validity of Aggression Based Dominance Measures in Male Laboratory Mice,Frontiers in veterinary science · 2021Article
- The feeding microstructure of male and female mice.PloS one · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Laboratory studies of social behavior have typically focused on dyadic interactions occurring within a limited spatiotemporal context. However, this strategy prevents analyses of the dynamics of group social behavior and constrains identification of the biological pathways mediating individual differences in behavior. In the current study, we aimed to identify the spatiotemporal dynamics and hierarchical organization of a large social network of male mice. We also sought to determine if standard assays of social and exploratory behavior are predictive of social behavior in this social network and whether individual network position was associated with the mRNA expression of two plasticity-related genes, DNA methyltransferase 1 and 3a. Mice were observed to form a hierarchically organized social network and self-organized into two separate social network communities. Members of both communities exhibited distinct patterns of socio-spatial organization within the vivaria that was not limited to only agonistic interactions. We further established that exploratory and social behaviors in standard behavioral assays conducted prior to placing the mice into the large group was predictive of initial network position and behavior but were not associated with final social network position. Finally, we determined that social network position is associated with variation in mRNA levels of two neural plasticity genes, DNMT1 and DNMT3a, in the hippocampus but not the mPOA. This work demonstrates the importance of understanding the role of social context and complex social dynamics in determining the relationship between individual differences in social behavior and brain gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.