Evidence map›Paper›PMID 27540020›Full record

ArticleThe European respiratory journal2016

Docosahexaenoic acid causes rapid pulmonary arterial relaxation via KCa channel-mediated hyperpolarisation in pulmonary hypertension.

Chandran Nagaraj, Bi Tang, Bence M Nagy, Rita Papp, Pritesh P Jain, Leigh M Marsh, Andrea L Meredith, Bahil Ghanim, Walter Klepetko, Grazyna Kwapiszewska and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in The European respiratory journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.5field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Article
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  5. Review
  6. Postnatal growth restriction impairs rat lung structure and function.Anatomical record (Hoboken, N.J. : 2007) · 2025
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Mechanisms of pulmonary vascular dysfunction in pulmonary hypertension and implications for novel therapies.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Nutraceuticals in the Treatment of Pulmonary Arterial Hypertension.International journal of molecular sciences · 2020
    Review
  18. MicroRNA-mediated downregulation of KAmerican journal of physiology. Lung cellular and molecular physiology · 2020
    Article
  19. The Journal of general physiology · 2019
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Chandran NagarajLudwig Boltzmann Institute for Lung Vascular Research, Graz, Austria Experimental Anesthesiology, Dept of Anesthesia and Intensive Care Medicine, Medical University of Graz, Graz, Austria.
Bi TangExperimental Anesthesiology, Dept of Anesthesia and Intensive Care Medicine, Medical University of Graz, Graz, Austria Dept of Cardiovascular Medicine, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui, PR China.
Bence M NagyLudwig Boltzmann Institute for Lung Vascular Research, Graz, Austria Institute of Physiology, Medical University of Graz, Graz, Austria.
Rita PappLudwig Boltzmann Institute for Lung Vascular Research, Graz, Austria.
Pritesh P JainLudwig Boltzmann Institute for Lung Vascular Research, Graz, Austria.
Leigh M MarshLudwig Boltzmann Institute for Lung Vascular Research, Graz, Austria.
Andrea L MeredithDept of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Bahil GhanimDivision of Thoracic Surgery, Dept of Surgery, Medical University of Vienna, Vienna, Austria.
Walter KlepetkoDivision of Thoracic Surgery, Dept of Surgery, Medical University of Vienna, Vienna, Austria.
Grazyna KwapiszewskaLudwig Boltzmann Institute for Lung Vascular Research, Graz, Austria Experimental Anesthesiology, Dept of Anesthesia and Intensive Care Medicine, Medical University of Graz, Graz, Austria.
E Kenneth WeirDept of Medicine, University of Minnesota, Minneapolis, MN, USA.
Horst OlschewskiDivision of Pulmonology, Dept of Internal Medicine, Medical University of Graz, Graz, Austria.
Andrea OlschewskiLudwig Boltzmann Institute for Lung Vascular Research, Graz, Austria Institute of Physiology, Medical University of Graz, Graz, Austria andrea.olschewski@lvr.lbg.ac.at.
Ludwig Boltzmann Institute for Lung Vascular Research · ATMedical University of Graz · ATMedical University of Vienna · ATFirst Affiliated Hospital of Bengbu Medical College · CNUniversity of Maryland, Baltimore · USUniversity of Minnesota · US

Funding

Daily Regulation of Ionic CurrentsR01HL102758 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI LEDERER, WILLIAM JONATHAN · 2010 to 2024
$6.3M
NHLBI NIH HHS R01 HL102758
6 · The paper itself

Abstract

Cardioprotective benefits of ω-3 fatty acids such as docosahexaenoic acid (DHA) are well established, but the regulatory effect of DHA on vascular tone and pressure in pulmonary hypertension is largely unknown.As DHA is a potent regulator of K

Indexed as

AdultAnimalsDocosahexaenoic AcidsFamilial Primary Pulmonary HypertensionFemaleHumansHypertension, PulmonaryHypoxiaLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsMaleMiceMice, KnockoutMiddle AgedMuscle, Smooth, VascularMyocytes, Smooth MusclePerfusionDocosahexaenoic AcidsKCNMA1 protein, humanKcnma1 protein, mouseLarge-Conductance Calcium-Activated Potassium Channel alpha Subunits

Identifiers

PMID27540020
PMCPMC5470640
OpenAlexW2511160768

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.