Evidence map›Paper›PMID 27539841›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2017

18F-Fluorosulfate for PET Imaging of the Sodium-Iodide Symporter: Synthesis and Biologic Evaluation In Vitro and In Vivo.

Alex Khoshnevisan, Krisanat Chuamsaamarkkee, Mehdi Boudjemeline, Alex Jackson, Gareth E Smith, Antony D Gee, Gilbert O Fruhwirth, Philip J Blower

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Recent Advances of S-ACS omega · 2023
    Review
  3. Direct Cell Radiolabeling forChemical reviews · 2022
    Review
  4. Review
  5. Article
  6. Review
  7. SpatiotemporalMolecular therapy. Methods & clinical development · 2021
    Article
  8. The chemical tool-kit for molecular imaging with radionuclides in the age of targeted and immune therapy.Cancer imaging : the official publication of the International Cancer Imaging Society · 2021
    Review
  9. Non-invasive Reporter Gene Imaging of Cell Therapies, including T Cells and Stem Cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2020
    Review
  10. Article
  11. How Non-invasiveFrontiers in physiology · 2020
    Review
  12. Review
  13. Positron emission tomography reporter gene strategy for use in the central nervous system.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  14. Fluorine-18: an untapped resource in inorganic chemistry.Chemical communications (Cambridge, England) · 2018
    Article
  15. Cousins at work: How combining medical with optical imaging enhances in vivo cell tracking.The international journal of biochemistry & cell biology · 2018
    Review
  16. Rapid Aqueous Late-Stage Radiolabelling of [GaFAngewandte Chemie (International ed. in English) · 2018
    Article
  17. Article
  18. [Theranostics · 2018
    Review
  19. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2017
    Article
  20. Sulfur - fluorine bond in PET radiochemistry.EJNMMI radiopharmacy and chemistry · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alex KhoshnevisanDivision of Imaging Sciences and Biomedical Engineering, St. Thomas' Hospital, King's College London, London, United Kingdom; and.
Krisanat ChuamsaamarkkeeDivision of Imaging Sciences and Biomedical Engineering, St. Thomas' Hospital, King's College London, London, United Kingdom; and.
Mehdi BoudjemelineDivision of Imaging Sciences and Biomedical Engineering, St. Thomas' Hospital, King's College London, London, United Kingdom; and.
Alex JacksonGE Healthcare, Amersham, United Kingdom.
Gareth E SmithGE Healthcare, Amersham, United Kingdom.
Antony D GeeDivision of Imaging Sciences and Biomedical Engineering, St. Thomas' Hospital, King's College London, London, United Kingdom; and.
Gilbert O FruhwirthDivision of Imaging Sciences and Biomedical Engineering, St. Thomas' Hospital, King's College London, London, United Kingdom; and.
Philip J BlowerDivision of Imaging Sciences and Biomedical Engineering, St. Thomas' Hospital, King's College London, London, United Kingdom; and philip.blower@kcl.ac.uk.

Funding

Cancer Research UK 21153Medical Research Council MC_PC_16048Wellcome Trust
6 · The paper itself

Abstract

Anion transport by the human sodium-iodide symporter (hNIS) is an established target for molecular imaging and radionuclide therapy. Current radiotracers for PET of hNIS expression are limited to

resultsFluorosulfate was identified as a potent inhibitor of

conclusionFluorosulfate is a high-affinity hNIS substrate.

Indexed as

AnimalsFemaleFluoridesFluorine RadioisotopesIsotope LabelingMetabolic Clearance RateMiceMice, Inbred BALB CMolecular ImagingOrgan SpecificityPositron-Emission TomographyRadiopharmaceuticalsReproducibility of ResultsSensitivity and SpecificitySodium-Iodide SymportersSulfuric AcidsFluoridesFluorine Radioisotopesfluorosulfonic acidRadiopharmaceuticalsSodium-Iodide SymportersSulfuric AcidsSymporters18Ffluorosulfatehuman sodium/iodide symporter (SC5A5)PETthyroid

Identifiers

PMID27539841
PMCPMC6233868

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.