Evidence map›Paper›PMID 27539837›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2017

2-Year Natural Decline of Cardiac Sympathetic Innervation in Idiopathic Parkinson Disease Studied with 11C-Hydroxyephedrine PET.

Ka Kit Wong, David M Raffel, Nicolaas I Bohnen, Gulcin Altinok, Sid Gilman, Kirk A Frey

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Dietary tributyrin supplementation in Parkinson's disease: An open-label target engagement study.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  2. Review
  3. Article
  4. Assessment of myocardial sympathetic innervation withJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  5. Assessment of myocardial sympathetic innervation with 18F-FDOPA-PET/CT in patients with autonomic dysfunction: feasibility study in IPD patients.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  6. The role of neuroimaging in Parkinson's disease.Journal of neurochemistry · 2021
    Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Observational
  14. Autonomic dysfunction in Parkinson disease and animal models.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019
    Review
  15. Imaging the Autonomic Nervous System in Parkinson's Disease.Current neurology and neuroscience reports · 2018
    Review
  16. Article
  17. Imaging Parkinson's disease below the neck.NPJ Parkinson's disease · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ka Kit WongDivision of Nuclear Medicine, Department of Radiology, University of Michigan, Ann Arbor, Michigan kakit@med.umich.edu.
David M RaffelDivision of Nuclear Medicine, Department of Radiology, University of Michigan, Ann Arbor, Michigan.
Nicolaas I BohnenDivision of Nuclear Medicine, Department of Radiology, University of Michigan, Ann Arbor, Michigan.
Gulcin AltinokDivision of Nuclear Medicine, Department of Radiology, University of Michigan, Ann Arbor, Michigan.
Sid GilmanDepartment of Neurology, University of Michigan (retired), Ann Arbor, Michigan; and.
Kirk A FreyDivision of Nuclear Medicine, Department of Radiology, University of Michigan, Ann Arbor, Michigan.
University of Michigan–Ann Arbor · USGeriatric Research Education and Clinical Center · USVA Ann Arbor Healthcare System · US

Funding

Public Outreach and Education CoreP50NS091856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALBIN, ROGER L · 2014 to 2019
$10.1M
NINDS NIH HHS P50 NS091856
6 · The paper itself

Abstract

The objective of this study was to detect regional patterns of cardiac sympathetic denervation in idiopathic Parkinson disease (IPD) using

methodsWe obtained 62 cardiac

resultsBaseline

conclusionProgressive decline in cardiac sympathetic neural integrity in IPD patients occurs at a modest rate over 2 y on

Indexed as

AgedAutonomic Nervous System DiseasesDisease ProgressionEphedrineFemaleHeartHumansLongitudinal StudiesMaleMiddle AgedParkinson DiseasePositron-Emission TomographyRadiopharmaceuticalsReproducibility of ResultsSensitivity and Specificity3-hydroxyephedrineEphedrineRadiopharmaceuticals11C-hydroxyephedrine PETautonomic nervous systemcardiac sympathetic denervationParkinson disease

Identifiers

PMID27539837
PMCPMC5288743
OpenAlexW2403316906

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.