ArticleAngewandte Chemie (International ed. in English)2016
Enantioselective Generation of Adjacent Stereocenters in a Copper-Catalyzed Three-Component Coupling of Imines, Allenes, and Diboranes.
Article in Angewandte Chemie (International ed. in English), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 146 citations in OpenAlex.
- Enantioselective Synthesis of 2,3-Disubstituted Azetidines via Copper-Catalyzed Boryl Allylation of Azetines.Journal of the American Chemical Society · 2025Article
- Enantioselective Copper-Catalyzed Borylative Cyclization for the Synthesis of Quinazolinones.Angewandte Chemie (International ed. in English) · 2021Article
- Copper-Catalyzed Borylative Couplings with C-N Electrophiles.Angewandte Chemie (International ed. in English) · 2020Review
- Copper-catalyzed functionalization of enynes.Chemical science · 2020Review
- Asymmetric synthesis of γ-chiral borylalkanesChemical science · 2020Article
- Beyond Carbon: Enantioselective and Enantiospecific Reactions with Catalytically Generated Boryl- and Silylcopper Intermediates.ACS central science · 2020Review
- Enantio- and diastereoselective conjugate borylation/Mannich cyclization.Chemical science · 2020Article
- Enantio- and Diastereoselective Synthesis of Homopropargyl Amines by Copper-Catalyzed Coupling of Imines, 1,3-Enynes, and Diborons.Angewandte Chemie (International ed. in English) · 2020Article
- Diastereo- and Enantioselective Synthesis of Homoallylic Amines Bearing Quaternary Carbon Centers.Journal of the American Chemical Society · 2020Article
- Cu-catalyzed C-C bond formation of vinylidene cyclopropanes with carbon nucleophiles.Chemical science · 2019Article
- α-Silicon effect assisted Curtin-Hammett allylation using allylcopper reagents derived from 1,3-dienylsilanes.Chemical science · 2019Article
- A Regio- and Stereodivergent Synthesis of Homoallylic Amines by a One-Pot Cooperative-Catalysis-Based Allylic Alkylation/Hofmann Rearrangement Strategy.Angewandte Chemie (International ed. in English) · 2019Review
- Delayed catalyst function enables direct enantioselective conversion of nitriles to NHScience (New York, N.Y.) · 2019Article
- Racemic Vinylallenes in Catalytic Enantioselective Multicomponent Processes: Rapid Generation of Complexity through 1,6-Conjugate Additions.Angewandte Chemie (International ed. in English) · 2019Article
- Intermolecular Metal-Catalyzed Reductive Coupling of Dienes, Allenes, and Enynes with Carbonyl Compounds and Imines.Chemical reviews · 2018Review
- Cu-catalyzed enantioselective synthesis of tertiary benzylic copper complexes and theirChemical science · 2018Article
- A Regio- and Enantioselective CuH-Catalyzed Ketone Allylation with Terminal Allenes.Journal of the American Chemical Society · 2018Article
- Enantioselective Rhodium-Catalyzed Coupling of Arylboronic Acids, 1,3-Enynes, and Imines by Alkenyl-to-Allyl 1,4-Rhodium(I) Migration.Angewandte Chemie (International ed. in English) · 2017Article
- Catalytic diastereo- and enantioselective additions of versatile allyl groups to N-H ketimines.Nature chemistry · 2017Article
- Copper-Catalyzed Borylacylation of Activated Alkenes with Acid Chlorides.Angewandte Chemie (International ed. in English) · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
A highly enantio- and diastereoselective copper-catalyzed three-component coupling affords the first general synthesis of homoallylic amines bearing adjacent stereocenters from achiral starting materials. The method utilizes a commercially available NHC ligand and copper source, operates at ambient temperature, couples readily available simple imines, allenes, and diboranes, and yields high-value homoallylic amines that exhibit versatile amino, alkenyl, and boryl units.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.