Evidence map›Paper›PMID 27539643›Full record

ArticleCancer causes & control : CCC2016

Association of sugary beverages with survival among patients with cancers of the upper aerodigestive tract.

Fayth L Miles, Shen-Chih Chang, Hal Morgenstern, Donald Tashkin, Jian-Yu Rao, Wendy Cozen, Thomas Mack, Qing-Yi Lu, Zuo-Feng Zhang

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Fayth L MilesDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, 650 Charles E. Young Dr. South, Los Angeles, CA, 90095-1772, USA.ORCID 0000-0002-9394-0047
Shen-Chih ChangDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, 650 Charles E. Young Dr. South, Los Angeles, CA, 90095-1772, USA.
Hal MorgensternDepartments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA.
Donald TashkinDivision of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Jian-Yu RaoDepartment of Pathology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Wendy CozenDepartments of Preventive Medicine and Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Thomas MackDepartments of Preventive Medicine and Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Qing-Yi LuCenter for Human Nutrition, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA.
Zuo-Feng ZhangDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, 650 Charles E. Young Dr. South, Los Angeles, CA, 90095-1772, USA. zfzhang@ucla.edu.
University of California, Los Angeles · USUniversity of Southern California · USUniversity of Michigan · US

Funding

UCLA SPORE IN LUNG CANCERP50CA090388 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2001 to 2008
$13.0M
Biobehavioral Cancer Prevention and Control Training ProgramR25CA092408 · NCI · UNIVERSITY OF WASHINGTON · PI PATRICK, DONALD LEE · 2001 to 2015
$7.1M
UCLA CANCER EPIDEMIOLOGY TRAINING PROGRAMT32CA009142 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, ZUO-FENG · 1986 to 2024
$6.3M
Stem Cell Selection &Expansion Via HOX Gene ActivationR01CA090833 · NCI · UNIVERSITY OF PENNSYLVANIA · PI EMERSON, STEPHEN G · 2001 to 2010
$2.6M
MARIJUANA USE AND THE RISKS OF LUNG AND OTHER CANCERSR01DA011386 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MORGENSTERN, HAL M · 1999 to 2003
$1.8M
Molecular Epidemiology and Gene-Environment InteractionR21ES011667 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, ZUO-FENG · 2002 to 2004
$651k
NCI NIH HHS P50 CA090388NCI NIH HHS R01 CA090833NCI NIH HHS R25 CA092408NCI NIH HHS T32 CA009142NIDA NIH HHS R01 DA011386NIEHS NIH HHS R21 ES011667
6 · The paper itself

Abstract

purposeThe role of consumption of added sugars in cancers of the upper aerodigestive tract (UADT) is unclear. We examined associations between sugary beverages and susceptibility to UADT cancer as well as overall survival among UADT cancer patients.

methodsThe association between dietary added sugar and susceptibility to UADT cancers or overall survival among 601 UADT cancer cases was evaluated using data from a population-based case-control study conducted in Los Angeles County. Unconditional logistic regression was used to estimate odds ratios and 95 % confidence intervals (CI) for cancer susceptibility, and Cox regression was used to estimate hazards ratios (HRs) with 95 % CIs for survival, adjusting for relevant confounders.

resultsA total of 248 deaths were observed during follow-up (median 12.1 years). A positive association was observed with consumption of grams of sugar from beverages, including soft drinks and fruit juices, and poorer survival among UADT cancer cases (aHR, Q4 vs. Q1:1.88; 95 % CI 1.29, 2.72; p for trend = 0.002), as well as servings of sugary beverages (aHR, Q4 vs. Q1: 95 % CI 1.97, 95 % CI 1.32-2.93). This was due largely to consumption of sugars from soft drinks. Particularly, high consumption of sugary beverages was associated with poorer survival among esophageal cancer cases, driven by squamous cancers. No association was observed between sugary beverages and cancer susceptibility.

conclusionThese findings suggest that consumption of sugary beverages may decrease survival associated with UADT cancers. Additional studies should be conducted to examine survival among cancer patients consuming high amounts of added or refined sugars. Such studies may highlight prognostic factors for UADT cancers.

Indexed as

AdultBeveragesCase-Control StudiesDietary SucroseEsophageal NeoplasmsFemaleHead and Neck NeoplasmsHumansMaleMiddle AgedPrognosisDietary SucroseCase–controlCox regressionHead and neck cancersSugary beveragesSurvival

Identifiers

PMID27539643
PMCPMC5552047
OpenAlexW2517371590

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.