ArticleThe American journal of psychiatry2017
No Association of Lower Hippocampal Volume With Alzheimer's Disease Pathology in Late-Life Depression.
Registry-linked trialOpen access · bronzeAbstract read
In one paragraph
Article in The American journal of psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07768098 (The Leuven Longitudinal Late-Life Depression Study), which is not on this map. Cited by 46 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 3 pooled it
4.9field-weighted citation impact, top 5% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT07768098 enrolling by invitationnot on this mapstarted 2026, after this paper: background citation
The Leuven Longitudinal Late-Life Depression Study
Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Structural and functional neuroimaging of late-life depression: a coordinate-based meta-analysis.Brain imaging and behavior · 2022Pooled it
- Volumetric brain differences in clinical depression in association with anxiety: a systematic review with meta-analysis.Journal of psychiatry & neuroscience : JPN · 2020Pooled it
- Depressive Symptoms in the Elderly-An Early Symptom of Dementia? A Systematic Review.Frontiers in pharmacology · 2020Pooled it
- Structural MRI-Based Measures of Accelerated Brain Aging do not Moderate the Acute Antidepressant Response in Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022Trial
- Lower regional gray matter volume in the absence of higher cortical amyloid burden in late-life depression.Scientific reports · 2021Trial
- Hippocampal Total, Subregion, and Subfield Volume Alterations in Late-Life Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Trajectories of late-life depression: insights from molecular imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Neuromodulation and cognition in late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Cerebral amyloid-β, glucose metabolism and hippocampal volume in major depression with and without suspected non-Alzheimer pathophysiology (SNAP).Alzheimer's research & therapy · 2025Article
- Diverse tau pathologies in late-life mood disorders revealed by PET and autopsy assays.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Cortico-limbic volume abnormalities in late life depression are distinct from β amyloid and white matter pathologies.Molecular psychiatry · 2025Article
- Depressive Symptoms and Amyloid Pathology.JAMA psychiatry · 2025Article
- Alzheimer's disease with depression: clinical characteristics and potential mechanisms involving orexin and brain atrophy.Translational psychiatry · 2025Article
- Gray and white matter differences in the medial temporal lobe in late-life depression: a multimodal PET-MRI investigation.Psychological medicine · 2025Article
- Amyloid deposition and its association with depressive symptoms and cognitive functions in late-life depression: a longitudinal study using amyloid-β PET images and neuropsychological measurements.Alzheimer's research & therapy · 2024Article
- Multimodal investigation of neuropathology and neurometabolites in mild cognitive impairment and late-life depression withNeurobiology of aging · 2024Article
- Repurposing Ketamine in the Therapy of Depression and Depression-Related Disorders: Recent Advances and Future Potential.Aging and disease · 2024Review
- Depressive symptoms and hippocampal volume in autosomal dominant Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Electroencephalographic markers in Major Depressive Disorder: insights from absolute, relative power, and asymmetry analyses.Frontiers in psychiatry · 2024Article
- Atrophy, hypometabolism and implication regarding pathology in late-life major depression with suspected non-alzheimer pathophysiology (SNAP).Biomedical journal · 2023Article
Corrections and comments
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Authors and funding
16 authors at 1 institution in 1 country.
François-Laurent De WinterFrom the Department of Old Age Psychiatry, University Psychiatric Center, KU Leuven, Belgium; Translational MRI, Department of Imaging and Pathology, KU Leuven, and Radiology, University Hospitals Leuven; Research and Development, Icometrix, Leuven; GE Healthcare, London; University Psychiatric Center, KU Leuven, and Academic Center for ECT and Neuromodulation, Kortenberg, Belgium; Laboratory for Cognitive Neurology, KU Leuven; the Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; the Department of Neurology, University Hospitals Leuven; Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven and University Hospitals Leuven.
Louise EmsellFrom the Department of Old Age Psychiatry, University Psychiatric Center, KU Leuven, Belgium; Translational MRI, Department of Imaging and Pathology, KU Leuven, and Radiology, University Hospitals Leuven; Research and Development, Icometrix, Leuven; GE Healthcare, London; University Psychiatric Center, KU Leuven, and Academic Center for ECT and Neuromodulation, Kortenberg, Belgium; Laboratory for Cognitive Neurology, KU Leuven; the Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; the Department of Neurology, University Hospitals Leuven; Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven and University Hospitals Leuven.
Filip BouckaertFrom the Department of Old Age Psychiatry, University Psychiatric Center, KU Leuven, Belgium; Translational MRI, Department of Imaging and Pathology, KU Leuven, and Radiology, University Hospitals Leuven; Research and Development, Icometrix, Leuven; GE Healthcare, London; University Psychiatric Center, KU Leuven, and Academic Center for ECT and Neuromodulation, Kortenberg, Belgium; Laboratory for Cognitive Neurology, KU Leuven; the Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; the Department of Neurology, University Hospitals Leuven; Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven and University Hospitals Leuven.
Lene ClaesFrom the Department of Old Age Psychiatry, University Psychiatric Center, KU Leuven, Belgium; Translational MRI, Department of Imaging and Pathology, KU Leuven, and Radiology, University Hospitals Leuven; Research and Development, Icometrix, Leuven; GE Healthcare, London; University Psychiatric Center, KU Leuven, and Academic Center for ECT and Neuromodulation, Kortenberg, Belgium; Laboratory for Cognitive Neurology, KU Leuven; the Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; the Department of Neurology, University Hospitals Leuven; Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven and University Hospitals Leuven.
Saurabh JainFrom the Department of Old Age Psychiatry, University Psychiatric Center, KU Leuven, Belgium; Translational MRI, Department of Imaging and Pathology, KU Leuven, and Radiology, University Hospitals Leuven; Research and Development, Icometrix, Leuven; GE Healthcare, London; University Psychiatric Center, KU Leuven, and Academic Center for ECT and Neuromodulation, Kortenberg, Belgium; Laboratory for Cognitive Neurology, KU Leuven; the Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; the Department of Neurology, University Hospitals Leuven; Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven and University Hospitals Leuven.
Gill FarrarFrom the Department of Old Age Psychiatry, University Psychiatric Center, KU Leuven, Belgium; Translational MRI, Department of Imaging and Pathology, KU Leuven, and Radiology, University Hospitals Leuven; Research and Development, Icometrix, Leuven; GE Healthcare, London; University Psychiatric Center, KU Leuven, and Academic Center for ECT and Neuromodulation, Kortenberg, Belgium; Laboratory for Cognitive Neurology, KU Leuven; the Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; the Department of Neurology, University Hospitals Leuven; Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven and University Hospitals Leuven.
Thibo BillietFrom the Department of Old Age Psychiatry, University Psychiatric Center, KU Leuven, Belgium; Translational MRI, Department of Imaging and Pathology, KU Leuven, and Radiology, University Hospitals Leuven; Research and Development, Icometrix, Leuven; GE Healthcare, London; University Psychiatric Center, KU Leuven, and Academic Center for ECT and Neuromodulation, Kortenberg, Belgium; Laboratory for Cognitive Neurology, KU Leuven; the Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; the Department of Neurology, University Hospitals Leuven; Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven and University Hospitals Leuven.
Stephan EversFrom the Department of Old Age Psychiatry, University Psychiatric Center, KU Leuven, Belgium; Translational MRI, Department of Imaging and Pathology, KU Leuven, and Radiology, University Hospitals Leuven; Research and Development, Icometrix, Leuven; GE Healthcare, London; University Psychiatric Center, KU Leuven, and Academic Center for ECT and Neuromodulation, Kortenberg, Belgium; Laboratory for Cognitive Neurology, KU Leuven; the Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; the Department of Neurology, University Hospitals Leuven; Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven and University Hospitals Leuven.
Jan Van den StockFrom the Department of Old Age Psychiatry, University Psychiatric Center, KU Leuven, Belgium; Translational MRI, Department of Imaging and Pathology, KU Leuven, and Radiology, University Hospitals Leuven; Research and Development, Icometrix, Leuven; GE Healthcare, London; University Psychiatric Center, KU Leuven, and Academic Center for ECT and Neuromodulation, Kortenberg, Belgium; Laboratory for Cognitive Neurology, KU Leuven; the Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; the Department of Neurology, University Hospitals Leuven; Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven and University Hospitals Leuven.
Pascal SienaertFrom the Department of Old Age Psychiatry, University Psychiatric Center, KU Leuven, Belgium; Translational MRI, Department of Imaging and Pathology, KU Leuven, and Radiology, University Hospitals Leuven; Research and Development, Icometrix, Leuven; GE Healthcare, London; University Psychiatric Center, KU Leuven, and Academic Center for ECT and Neuromodulation, Kortenberg, Belgium; Laboratory for Cognitive Neurology, KU Leuven; the Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; the Department of Neurology, University Hospitals Leuven; Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven and University Hospitals Leuven.
Jasmien ObbelsFrom the Department of Old Age Psychiatry, University Psychiatric Center, KU Leuven, Belgium; Translational MRI, Department of Imaging and Pathology, KU Leuven, and Radiology, University Hospitals Leuven; Research and Development, Icometrix, Leuven; GE Healthcare, London; University Psychiatric Center, KU Leuven, and Academic Center for ECT and Neuromodulation, Kortenberg, Belgium; Laboratory for Cognitive Neurology, KU Leuven; the Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; the Department of Neurology, University Hospitals Leuven; Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven and University Hospitals Leuven.
Stefan SunaertFrom the Department of Old Age Psychiatry, University Psychiatric Center, KU Leuven, Belgium; Translational MRI, Department of Imaging and Pathology, KU Leuven, and Radiology, University Hospitals Leuven; Research and Development, Icometrix, Leuven; GE Healthcare, London; University Psychiatric Center, KU Leuven, and Academic Center for ECT and Neuromodulation, Kortenberg, Belgium; Laboratory for Cognitive Neurology, KU Leuven; the Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; the Department of Neurology, University Hospitals Leuven; Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven and University Hospitals Leuven.
Katarzyna AdamczukFrom the Department of Old Age Psychiatry, University Psychiatric Center, KU Leuven, Belgium; Translational MRI, Department of Imaging and Pathology, KU Leuven, and Radiology, University Hospitals Leuven; Research and Development, Icometrix, Leuven; GE Healthcare, London; University Psychiatric Center, KU Leuven, and Academic Center for ECT and Neuromodulation, Kortenberg, Belgium; Laboratory for Cognitive Neurology, KU Leuven; the Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; the Department of Neurology, University Hospitals Leuven; Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven and University Hospitals Leuven.
Rik VandenbergheFrom the Department of Old Age Psychiatry, University Psychiatric Center, KU Leuven, Belgium; Translational MRI, Department of Imaging and Pathology, KU Leuven, and Radiology, University Hospitals Leuven; Research and Development, Icometrix, Leuven; GE Healthcare, London; University Psychiatric Center, KU Leuven, and Academic Center for ECT and Neuromodulation, Kortenberg, Belgium; Laboratory for Cognitive Neurology, KU Leuven; the Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; the Department of Neurology, University Hospitals Leuven; Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven and University Hospitals Leuven.
Koen Van LaereFrom the Department of Old Age Psychiatry, University Psychiatric Center, KU Leuven, Belgium; Translational MRI, Department of Imaging and Pathology, KU Leuven, and Radiology, University Hospitals Leuven; Research and Development, Icometrix, Leuven; GE Healthcare, London; University Psychiatric Center, KU Leuven, and Academic Center for ECT and Neuromodulation, Kortenberg, Belgium; Laboratory for Cognitive Neurology, KU Leuven; the Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; the Department of Neurology, University Hospitals Leuven; Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven and University Hospitals Leuven.
Mathieu VandenbulckeFrom the Department of Old Age Psychiatry, University Psychiatric Center, KU Leuven, Belgium; Translational MRI, Department of Imaging and Pathology, KU Leuven, and Radiology, University Hospitals Leuven; Research and Development, Icometrix, Leuven; GE Healthcare, London; University Psychiatric Center, KU Leuven, and Academic Center for ECT and Neuromodulation, Kortenberg, Belgium; Laboratory for Cognitive Neurology, KU Leuven; the Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston; the Department of Neurology, University Hospitals Leuven; Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven and University Hospitals Leuven.
KU Leuven · BE
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHippocampal volume is commonly decreased in late-life depression. According to the depression-as-late-life-neuropsychiatric-disorder model, lower hippocampal volume in late-life depression is associated with neurodegenerative changes. The purpose of this prospective study was to examine whether lower hippocampal volume in late-life depression is associated with Alzheimer's disease pathology.
methodOf 108 subjects who participated, complete, good-quality data sets were available for 100: 48 currently depressed older adults and 52 age- and gender-matched healthy comparison subjects who underwent structural MRI, [
resultsA significant difference was observed in mean normalized total hippocampal volume between patients and comparison subjects, but there were no group differences in cortical amyloid uptake or proportion of amyloid-positive subjects. The difference in hippocampal volume remained significant after the amyloid-positive subjects were excluded. There was no association between hippocampal volume and amyloid uptake in either patients or comparison subjects.
conclusionsLower hippocampal volume was not related to amyloid pathology in this sample of patients with late-life depression. These data counter the common belief that changes in hippocampal volume in late-life depression are due to prodromal Alzheimer's disease.
Indexed as
AgedAged, 80 and overAlzheimer DiseaseAmyloidAniline CompoundsAtrophyBelgiumBenzothiazolesCerebral CortexDepressive DisorderFemaleFluorine RadioisotopesHippocampusHumansImage Interpretation, Computer-AssistedImaging, Three-DimensionalAmyloidAniline CompoundsBenzothiazolesFluorine RadioisotopesflutemetamolAlzheimer’s diseaseamyloidbrain imaginggeriatric psychiatryhippocampal volumeLate-life depression
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Registered trials
NCT07768098ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.