Evidence map›Paper›PMID 27539476›Full record

ArticleJournal of neuropathology and experimental neurology2016

Protein Analysis of Glioblastoma Primary and Posttreatment Pairs Suggests a Mesenchymal Shift at Recurrence.

Matthew D Wood, Gerald F Reis, David E Reuss, Joanna J Phillips

Abstract read
In one paragraph

Article in Journal of neuropathology and experimental neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  14. PotentFrontiers in oncology · 2023
    Article
  15. Article
  16. Article
  17. Review
  18. Perspective of mesenchymal transformation in glioblastoma.Acta neuropathologica communications · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Matthew D WoodFrom the Division of Neuropathology, Department of Pathology (MDW, GFR, JJP) and Department of Neurological Surgery (JJP), University of California San Francisco, San Francisco, California; and Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University, Heidelberg, Germany (DER).
Gerald F ReisFrom the Division of Neuropathology, Department of Pathology (MDW, GFR, JJP) and Department of Neurological Surgery (JJP), University of California San Francisco, San Francisco, California; and Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University, Heidelberg, Germany (DER).
David E ReussFrom the Division of Neuropathology, Department of Pathology (MDW, GFR, JJP) and Department of Neurological Surgery (JJP), University of California San Francisco, San Francisco, California; and Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University, Heidelberg, Germany (DER).
Joanna J PhillipsFrom the Division of Neuropathology, Department of Pathology (MDW, GFR, JJP) and Department of Neurological Surgery (JJP), University of California San Francisco, San Francisco, California; and Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University, Heidelberg, Germany (DER). joanna.phillips@ucsf.edu.

Funding

Project 4: Multi-modality Metabolic Imaging for Monitoring Molecular Sub-types of GliomaP01CA118816 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Pavithra Viswanath · 2007 to 2026
$44.7M
Training Program in Translational Brain Tumor ResearchT32CA151022 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2010 to 2026
$6.6M
Heparan sulfate proteoglycans as critical regulators of brain cancer malignancyR01NS081117 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PHILLIPS, JOANNA · 2012 to 2016
$1.7M
NCI NIH HHS P01 CA118816NCI NIH HHS T32 CA151022NINDS NIH HHS R01 NS081117
6 · The paper itself

Abstract

Glioblastomas (GBM) are aggressive brain tumors that inevitably recur despite surgical resection, chemotherapy, and radiation. The degree to which recurrent GBM retains its initial immunophenotype is incompletely understood. We generated tissue microarrays of paired initial and posttreatment GBM (3 pairs positive and 17 negative for IDH1

Indexed as

GlioblastomaGlioblastoma molecular subtypeImmunohistochemistryMesenchymal transitionNeurofibrominRecurrent glioblastoma.

Identifiers

PMID27539476
PMCPMC6281078

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.