ArticleScientific reports2016
Silicon Nitride: A Synthetic Mineral for Vertebrate Biology.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 58 citations in OpenAlex.
- Bone Fusion in the Cervical Spine: Where Are We Now?Bioengineering (Basel, Switzerland) · 2026Review
- Fabrication and Characterization of a Stretchable Sodium Alginate Hydrogel Patch Combined with Silicon Nitride and Metalized Halloysite Nanotubes to Develop a Chronic Wound Healing Treatment.International journal of molecular sciences · 2025Article
- Biomechanical Evaluation of Cervical Interbody Fusion Cages for Anterior Cervical Discectomy and Fusion With Variations in Morphology: A Finite Element Analysis.Biomedical engineering and computational biology · 2025Article
- Instantaneous Inactivation of Herpes Simplex Virus by Silicon Nitride Bioceramics.International journal of molecular sciences · 2023Article
- Silicon Nitride Ceramics: Structure, Synthesis, Properties, and Biomedical Applications.Materials (Basel, Switzerland) · 2023Review
- Various Types of Light Guides for Use in Lossy Mode Resonance-Based Sensors.Sensors (Basel, Switzerland) · 2023Article
- The SNAP Trial: 2-Year Results of a Double-Blind Multicenter Randomized Controlled Trial of a Silicon Nitride Versus a PEEK Cage in Patients After Lumbar Fusion Surgery.Global spine journal · 2022Article
- Silicon Oxynitride Thin Film Coating to Lossy Mode Resonance Fiber-Optic Refractometer.Sensors (Basel, Switzerland) · 2022Article
- A comparative study on silicon nitride, titanium and polyether ether ketone on mouse pre-osteoblast cells.Medical devices & sensors · 2021Article
- Two-year results of a double-blind multicenter randomized controlled non-inferiority trial of polyetheretherketone (PEEK) versus silicon nitride spinal fusion cages in patients with symptomatic degenerative lumbar disc disorders.Journal of spine surgery (Hong Kong) · 2020Article
- Clinical outcomes for lumbar fusion using silicon nitride versus other biomaterials.Journal of spine surgery (Hong Kong) · 2020Article
- Clinical outcomes for anterior cervical discectomy and fusion with silicon nitride spine cages: a multicenter study.Journal of spine surgery (Hong Kong) · 2019Article
- Off-Stoichiometric Reactions at the Cell-Substrate Biomolecular Interface of Biomaterials:International journal of molecular sciences · 2019Article
- Silicon nitride enhances osteoprogenitor cell growth and differentiation via increased surface energy and formation of amide and nanocrystalline HA for craniofacial reconstruction.Medical devices & sensors · 2019Article
- Biological Impact of Silicon Nitride for Orthopaedic Applications: Role of Particle Size, Surface Composition and Donor Variation.Scientific reports · 2018Article
- A single center retrospective clinical evaluation of anterior cervical discectomy and fusion comparing allograft spacers to silicon nitride cages.Journal of spine surgery (Hong Kong) · 2018Article
- Correlative atomic force microscopy quantitative imaging-laser scanning confocal microscopy quantifies the impact of stressors on live cells in real-time.Scientific reports · 2018Article
- Bioactive silicon nitride: A new therapeutic material for osteoarthropathy.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The remarkable stoichiometric flexibility of hydroxyapatite (HAp) enables the formation of a variety of charged structural sites at the material's surface which facilitates bone remodeling due to binding of biomolecule moieties in zwitterionic fashion. In this paper, we report for the first time that an optimized biomedical grade silicon nitride (Si3N4) demonstrated cell adhesion and improved osteoconductivity comparable to highly defective, non-stoichiometric natural hydroxyapatite. Si3N4's zwitterionic-like behavior is a function of the dualism between positive and negative charged off-stoichiometric sites (i.e., N-vacancies versus silanols groups, respectively). Lattice defects at the biomaterial's surface greatly promote interaction with positively- and negatively-charged functional groups in biomolecules, and result in the biologically effective characteristics of silicon nitride. These findings are anticipated to be a starting point for further discoveries of therapeutic bone-graft substitute materials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.