ReviewJournal of neurovirology2017
Roseolovirus-associated encephalitis in immunocompetent and immunocompromised individuals.
Review in Journal of neurovirology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 85 citations in OpenAlex.
- Review
- Central nervous system infection associated with Human herpesvirus 7 presenting with predominant persecutory delusions as initial psychiatric manifestations after allogeneic stem cell transplantation: a rare case report with diagnostic and therapeutic implications.BMC infectious diseases · 2026Article
- Neuropsychiatric Symptoms After HHV-6 Encephalitis in an Immunocompetent Child: A Case Report.The American journal of case reports · 2025Article
- Human herpes virus-7-related severe encephalitis diagnosed using mNGS in immunocompetent pediatric patients.Virology journal · 2025Review
- Herpesvirus initiation of dementias and autoimmune diseases.Journal of neurovirology · 2025Review
- Clinical spectrum of AES (Acute encephalitis syndrome) and a syndromic approach for its diagnosis.Journal of neurovirology · 2025Article
- Acute Meningitis/Encephalitis Presumably Secondary to Human Herpesvirus 6: A Case Report.Cureus · 2025Article
- Evaluation of Inborn Errors of Immunity Among Patients with Opportunistic Pulmonary Infection.Clinics in chest medicine · 2025Review
- Comparative Efficacy of Different Pharmacological Treatments for Pityriasis Rosea: A Network Meta-Analysis.Journal of clinical medicine · 2024Review
- Cytomegalovirus in Adenoma and Carcinoma Lesions: Detecting Mono-Infection and Co-Infection in Salivary Glands.International journal of molecular sciences · 2024Article
- Hybrid capture shotgun sequencing detected unexpected viruses in the cerebrospinal fluid of children with acute meningitis and encephalitis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Article
- Symptomatic central nervous system tuberculosis and human herpesvirus-6 coinfection with associated hydrocephalus managed with endoscopic third ventriculostomy: A case report and review of human herpesvirus-6 neuropathology.Surgical neurology international · 2024Article
- Prevalence of Anti-Human Herpes Virus Type 7 IgG Positivity Rate among Children with Fever and Skin Rash in Diyala Province, Iraq.Archives of Razi Institute · 2023Article
- Shotgun metagenomics to investigate unknown viral etiologies of pediatric meningoencephalitis.PloS one · 2023Article
- Etiological Analysis of Viral Encephalitis in Children in Zhejiang Province from 2018 to 2019.Diagnostics (Basel, Switzerland) · 2022Article
- 40 Years after the Registration of Acyclovir: Do We Need New Anti-Herpetic Drugs?International journal of molecular sciences · 2022Review
- Human Herpes Virus 7-related encephalopathy in children.Acta bio-medica : Atenei Parmensis · 2022Article
- Challenges in the Diagnosis of Viral Encephalitis in Children: The Case of Two Siblings.Infectious disease reports · 2022Article
- Herpesvirus-Associated Encephalitis: an Update.Current tropical medicine reports · 2022Review
- Family Herpesviridae and neuroinfections: current status and research in progress.Memorias do Instituto Oswaldo Cruz · 2022Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The roseoloviruses, human herpesvirus (HHV)-6A, HHV-6B, and HHV-7, can cause severe encephalitis or encephalopathy. In immunocompetent children, primary HHV-6B infection is occasionally accompanied by diverse clinical forms of encephalitis. Roseolovirus coinfections with heterologous viruses and delayed primary HHV-7 infection in immunocompetent adults result in very severe neurological and generalized symptoms. Recovery from neurological sequelae is slow and sometimes incomplete. In immunocompromised patients with underlying hematological malignancies and transplantation, frequent single or simultaneous reactivation of roseoloviruses elicit severe, lethal organ dysfunctions, including damages in the limbic system, brain stem, and hippocampus. Most cases have been due to HHV-6B with HHV-6A accounting for 2-3%. The most severe manifestation of HHV-6B reactivation is post-transplantation limbic encephalitis. Seizures, cognitive problems, and abnormal EEG are common. Major risk factors for HHV-6B-associated encephalitis include unrelated cord blood cell transplantation and repeated hematopoietic stem cell transplantation. Rare genetic disorders, male gender, certain HLA constellation, and immune tolerance to replicating HHV-6 in persons carrying chromosomally integrated HHV-6 might also predispose an individual to roseolovirus-associated brain damage. At this time, little is known about the risk factors for HHV-7-associated encephalitis. Intrathecal glial cell destruction due to virus replication, overexpression of proinflammatory cytokines, and viral mimicry of chemokines all contribute to brain dysfunction. High virus load in the cerebrospinal fluid, hippocampal astrogliosis, and viral protein expression in HHV-6B-associated cases and multiple microscopic neuronal degeneration in HHV-7-associated cases are typical laboratory findings. Early empirical therapy with ganciclovir or foscarnet might save the life of a patient with roseolovirus-associated encephalitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.