Evidence map›Paper›PMID 27538994›Full record

ArticleJournal of neurovirology2017

Development and characterization of a human microglia cell model of HIV-1 infection.

Pratima Rawat, Stephen A Spector

Abstract read
In one paragraph

Article in Journal of neurovirology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
  2. Chiropteran (Animals : an open access journal from MDPI · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Role of microglia in HIV-1 infection.AIDS research and therapy · 2023
    Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Pratima RawatDepartment of Pediatrics, Division of Infectious Diseases, University of California San Diego, La Jolla, CA, 92093-0672, USA.
Stephen A SpectorDepartment of Pediatrics, Division of Infectious Diseases, University of California San Diego, La Jolla, CA, 92093-0672, USA. saspector@ucsd.edu.

Funding

International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) GroupU01AI068632 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI JACKSON, J BROOKS · 2006 to 2010
$109.7M
VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Maile Ann Young Karris · 1994 to 2026
$78.4M
Host Genetic Factors Associated with CNS Disease of HIV-Infected ChildrenR01NS077874 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SPECTOR, STEPHEN A · 2011 to 2015
$3.6M
Nanopeptide Targeting of HIV-CNS Reservoirs without ReactivationR01NS104015 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SPECTOR, STEPHEN A · 2017 to 2021
$2.9M
Modulating Autophagy to Eradicate HIV-1 from CNS ReservoirsR01NS084912 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SPECTOR, STEPHEN A · 2013 to 2017
$1.9M
PEDIATRIC AIDS--FACTORS IN TRANSMISSION AND PATHOLOGYR01AI039004 · NIAID · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI SPECTOR, STEPHEN A · 1995 to 2005
$1.5M
NIAID NIH HHS P30 AI036214NIAID NIH HHS R01 AI039004NIAID NIH HHS U01 AI068632NICHD NIH HHS HHSN267200800001CNIDDK NIH HHS HHSN267200800001GNINDS NIH HHS R01 NS077874NINDS NIH HHS R01 NS084912NINDS NIH HHS R01 NS104015
6 · The paper itself

Abstract

Microglia cells are the major reservoir of HIV-1 (HIV) within the CNS. However, current models using transformed cell lines are not representative of primary microglia and fetal brain samples for isolation of primary human microglia (HMG) are increasingly difficult to obtain. Here, we describe a monocyte-derived microglia (MMG) cell model of HIV infection that recapitulates infection of primary HMG. CD14

Indexed as

Models, BiologicalAntigens, CDBiomarkersCell DifferentiationCell ShapeChemokine CCL2Gene ExpressionGranulocyte-Macrophage Colony-Stimulating FactorHIV-1HIV Core Protein p24HumansMacrophage Colony-Stimulating FactorMicrogliaMicroRNAsMonocytesNerve Growth FactorAntigens, CDBiomarkersCCL2 protein, humanChemokine CCL2Granulocyte-Macrophage Colony-Stimulating FactorHIV Core Protein p24Macrophage Colony-Stimulating FactorMicroRNAsNerve Growth FactorReactive Oxygen SpeciesHIV-1HMGHuman microgliaMMGMonocyte-derived microglia

Identifiers

PMID27538994
PMCPMC5593752

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.