ArticleAJNR. American journal of neuroradiology2016
CT Perfusion in Acute Lacunar Stroke: Detection Capabilities Based on Infarct Location.
Article in AJNR. American journal of neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 49 citations in OpenAlex.
- Trial
- CT Perfusion in lacunar stroke: a powerful tool to enhance lacunar stroke detection and prediction of patients' outcome.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- The imaging-quiescent phenotype in thrombolysed acute ischemic stroke: a diffusion-weighted MRI-based deconstruction.Frontiers in neuroscience · 2026Article
- Machine learning enhanced noninvasive transcranial stroke detection using a portable eddy current damping sensor.iScience · 2025Article
- Regional Hypoperfusion Predicts White Matter Tract Degeneration in Recent Single Subcortical Infarcts.Journal of the American Heart Association · 2025Article
- Assessing the accuracy of automated CT perfusion software in excluding acute stroke: a comparative study of two software packages.Frontiers in neuroimaging · 2025Article
- Multimodal imaging evaluation of early neurological deterioration following acute ischemic stroke.Quantitative imaging in medicine and surgery · 2024Article
- Regional Reliability of Combining CT Angiography-source Image and Non-contrast CT in Acute Ischemic Stroke.International journal of medical sciences · 2024Article
- CT perfusion imaging in aneurysmal subarachnoid hemorrhage. State of the art.Frontiers in radiology · 2024Review
- Nomogram Based on Dual-Layer Spectral Detector CTA Parameter for the Prediction of Infarct Core in Patients with Acute Ischemic Stroke.Diagnostics (Basel, Switzerland) · 2023Article
- Improved Visualization and Quantification of Net Water Uptake in Recent Small Subcortical Infarcts in the Thalamus Using Computed Tomography.Diagnostics (Basel, Switzerland) · 2023Article
- Perfusion Status in Lacunar Stroke: A Pathophysiological Issue.Diagnostics (Basel, Switzerland) · 2023Review
- CT Perfusion in Lacunar Stroke: A Systematic Review.Diagnostics (Basel, Switzerland) · 2023Review
- The value of computed tomography perfusion deficit volumes in acute isolated brainstem infarction.Frontiers in neurology · 2023Article
- Association of concomitant headache with hypoperfusion in ischemic stroke: A multimodal CT-based study.Clinical and translational science · 2022Article
- Diagnostic value of whole-brain computed tomographic perfusion imaging for suspected large artery occlusion stroke patients in emergency department.Acta neurologica Belgica · 2022Article
- Impact Analysis of Different CT Configurations of Carotid Artery Plaque Calcifications on Cerebrovascular Events.AJNR. American journal of neuroradiology · 2022Article
- The Potential Impact of Neuroimaging and Translational Research on the Clinical Management of Lacunar Stroke.International journal of molecular sciences · 2022Review
- Detection of impending perfusion deficits by intraoperative computed tomography (iCT) in aneurysm surgery of the anterior circulation.Acta neurochirurgica · 2021Article
- Hemispheric cerebral blood flow predicts outcome in acute small subcortical infarcts.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeRecent studies demonstrated superiority of CTP to NCCT/CTA at detecting lacunar infarcts. This study aimed to assess CTP's capability to identify lacunae in different intracranial regions. MATERIALS AND
methodsOver 5.5 years, 1085 CTP examinations were retrospectively reviewed in patients with acute stroke symptoms with CTP within 12 hours and MRI within 7 days of symptom onset. Patients had infarcts ≤2 cm or no acute infarct on DWI; patients with concomitant infarcts >2 cm on DWI were excluded. CTP postprocessing was automated by a delay-corrected algorithm. Three blinded reviewers were given patient NIHSS scores and symptoms; infarcts were recorded based on NCCT/CTA, CTP (CBF, CBV, MTT, and TTP), and DWI.
resultsOne hundred thirteen patients met inclusion criteria (53.1% female). On DWI, lacunar infarcts were present in 37 of 113 (32.7%), and absent in 76 of 113 (67.3%). On CTP, lacunar infarcts typically appeared as abnormalities larger than infarct size on DWI. Interobserver κ for CTP ranged from 0.38 (CBF) (P < .0001) to 0.66 (TTP) (P < .0001); interobserver κ for DWI was 0.88 (P < 0.0001). In all intracranial regions, sensitivity of CTP ranged from 18.9% (CBV) to 48.7% (TTP); specificity ranged from 97.4% (CBF and TTP) to 98.7% (CBV and MTT). CTP's sensitivity was highest in the subcortical white matter with or without cortical involvement (21.7%-65.2%) followed by periventricular white matter (12.5%-37.5%); sensitivity in the thalami or basal ganglia was 0%.
conclusionsCTP has low sensitivity and high specificity in identifying lacunar infarcts. Sensitivity is highest in the subcortical white matter with or without cortical involvement, but limited in the basal ganglia and thalami.
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