Evidence map›Paper›PMID 27538776›Full record

ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2016

Single dose IOERT versus whole breast irradiation : Cosmetic results in breast-conserving therapy.

Henk Struikmans, Malou Snijders, Mirjam E Mast, Ursula Fisscher, Jan-Huib Franssen, Marcelle J Immink, Andreas Marinelli, Jos Merkus, Anna Petoukhova, Gabrielle Speijer and 1 more

Abstract readControlled Clinical Trial
PubMed Publisher
In one paragraph

Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. The evolution of targeted intra operative radiotherapy in early breast cancer.Journal of cancer research and clinical oncology · 2025
    Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Henk StruikmansRadiotherapy Centre West, Medical Centre Haaglanden, Lijnbaan 32, 2501 CK, The Hague, The Netherlands. h.struikmans@mchaaglanden.nl.
Malou SnijdersRadiotherapy Centre West, Medical Centre Haaglanden, Lijnbaan 32, 2501 CK, The Hague, The Netherlands.
Mirjam E MastRadiotherapy Centre West, Medical Centre Haaglanden, Lijnbaan 32, 2501 CK, The Hague, The Netherlands.
Ursula FisscherRadiotherapy Centre West, Medical Centre Haaglanden, Lijnbaan 32, 2501 CK, The Hague, The Netherlands.
Jan-Huib FranssenDepartment of Radiotherapy, HAGA Medical Centre, Leyweg 275, 2545 CH, The Hague, The Netherlands.
Marcelle J ImminkDepartment of Radiotherapy, Reinier de Graaf Medical Centre, Reinier de Graafweg 3/11, 2625 AD, Delft, The Netherlands.
Andreas MarinelliDepartment of Surgery, Medical Centre Haaglanden, Lijnbaan 32, 2501 CK, The Hague, The Netherlands.
Jos MerkusDepartment of Surgery, HAGA Medical Centre, Leyweg 275, 2545 CH, The Hague, The Netherlands.
Anna PetoukhovaRadiotherapy Centre West, Medical Centre Haaglanden, Lijnbaan 32, 2501 CK, The Hague, The Netherlands.
Gabrielle SpeijerDepartment of Radiotherapy, HAGA Medical Centre, Leyweg 275, 2545 CH, The Hague, The Netherlands.
Peter KoperRadiotherapy Centre West, Medical Centre Haaglanden, Lijnbaan 32, 2501 CK, The Hague, The Netherlands.
Medisch Centrum Haaglanden · NLHaga Hospital · NLLeiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundScarce data are available about the cosmetic result of single dose intraoperative electron radiotherapy (IOERT) in breast-conserving radiotherapy. METHODS AND MATERIALS: We included 71 breast cancer patients. Breast-conserving surgery and sentinel node procedure had started almost 3 years earlier. Subsequently, 26 patients were treated with IOERT and 45 patients received postoperative whole breast irradiation (WBI). For both groups we determined seven dimensionless asymmetry features. We compared the subjectively and the objectively derived cosmetic scores with each other.

resultsFor four asymmetry features we noted significantly smaller differences for patients treated with IOERT when compared to those treated with WBI: relative breast contour difference, relative breast area difference and relative breast overlap difference. After correcting for excision volume a significant difference was noticed also for relative lower breast contour. For the IOERT group the cosmetic scores "excellent or good" as determined by each patient and one physician were 88 and 96 %, respectively. When the overall cosmetic scores for patients treated with IOERT and WBI were compared to those of the objectively derived scores, there was a fair level of agreement.

conclusionFor patients treated with IOERT we noted less asymmetry and high rates of "good or excellent" subjectively derived cosmetic scores. The level of agreement between the subjectively and the objectively derived cosmetic scores was limited. Due to the small sample size and the design of the study no definitive conclusions can be drawn.

Indexed as

Cosmetic TechniquesDose Fractionation, RadiationAgedBreast NeoplasmsElectronsFemaleHumansIntraoperative CareMastectomyMastectomy, SegmentalMiddle AgedOrgan Sparing TreatmentsRadiotherapy, AdjuvantRadiotherapy DosageTreatment OutcomeAccelerated partial breast irradiationAsymmetryIntraoperative electron radiotherapyLumpectomyRadiotherapy

Identifiers

PMID27538776
OpenAlexW2524857100

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.