Evidence map›Paper›PMID 27538743›Full record

Trial reportCancer prevention research (Philadelphia, Pa.)2016

Harnessing the Power of Cruciferous Vegetables: Developing a Biomarker for Brassica Vegetable Consumption Using Urinary 3,3'-Diindolylmethane.

Naomi Fujioka, Benjamin W Ransom, Steven G Carmella, Pramod Upadhyaya, Bruce R Lindgren, Astia Roper-Batker, Dorothy K Hatsukami, Vincent A Fritz, Charles Rohwer, Stephen S Hecht

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer prevention research (Philadelphia, Pa.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Employing Dietary Comparators to Perform Risk Assessments for Anti-Androgens Without Using Animal Data.Toxicological sciences : an official journal of the Society of Toxicology · 2019
    Article
  10. Isothiocyanates: Translating the Power of Plants to People.Molecular nutrition & food research · 2018
    Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Naomi FujiokaDivision of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, Minnesota. Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota. fujio002@umn.edu.
Benjamin W RansomMasonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Steven G CarmellaMasonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Pramod UpadhyayaMasonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Bruce R LindgrenMasonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Astia Roper-BatkerCollege of Medicine, University of Vermont, Burlington, Vermont.
Dorothy K HatsukamiMasonic Cancer Center, University of Minnesota, Minneapolis, Minnesota. Tobacco Research Programs, University of Minnesota, Minneapolis, Minnesota.
Vincent A FritzDepartment of Horticultural Science, University of Minnesota, St. Paul, Minnesota. Southern Research and Outreach Center, University of Minnesota, Waseca, Minnesota.
Charles RohwerSouthern Research and Outreach Center, University of Minnesota, Waseca, Minnesota.
Stephen S HechtMasonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
University of Minnesota · US

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Douglas Yee · 1998 to 2026
$100.4M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
TRAINING IN HEMOGLOBIN &CELL MEMBRANE RESEARCHT32HL007062 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Jeffrey S. Miller, Gregory M Vercellotti · 1985 to 2026
$10.3M
NCATS NIH HHS UL1 TR000114NCI NIH HHS P30 CA077598NHLBI NIH HHS T32 HL007062
6 · The paper itself

Abstract

Glucobrassicin in Brassica vegetables gives rise to indole-3-carbinol (I3C), a compound with potent anticancer effects in preclinical models. We previously showed that the urinary metabolite 3,3'-diindolylmethane (DIM) could discriminate between volunteers fed high and low doses of Brassica vegetables. However, the quantitative relationship between glucobrassicin exposure and urinary DIM level is unclear. We conducted a clinical trial to examine the hypotheses that a range of glucobrassicin exposure from Brassica vegetables is reflected in urinary DIM and that this effect plateaus. Forty-five subjects consumed vegetables, a mixture of brussels sprouts and/or cabbage, at one of seven discrete dose levels of glucobrassicin ranging from 25 to 500 μmol, once daily for 2 consecutive days. All urine was collected for 24 hours after each vegetable-eating session. Urinary DIM was measured using our published liquid chromatography-electrospray ionization-tandem mass spectrometry-selected reaction monitoring (LC/ESI-MS/MS-SRM) method. Urinary DIM excretion increased predictably with increasing glucobrassicin dose and plateaued between 200 and 300 μmol of glucobrassicin. The association between glucobrassicin dose and urinary DIM was strong and positive (R

Indexed as

BrassicaDietAdultBiomarkersChromatography, LiquidGlucosinolatesHumansIndolesMiddle AgedTandem Mass SpectrometryYoung Adult3,3'-diindolylmethaneBiomarkersglucobrassicinGlucosinolatesIndoles

Identifiers

PMID27538743
PMCPMC5220883
OpenAlexW2510316226

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.