ArticleScientific reports2016
Live volumetric (4D) visualization and guidance of in vivo human ophthalmic surgery with intraoperative optical coherence tomography.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 62 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intraoperative OCT Guidance of Intraocular Surgery
First Use of Duke 4D Microscope Integrated OCT (MIOCT) Integrated Into Zeiss Artevo 800 Ophthalmic Surgical Microscope in the Operating Room
Who cites it
62 citing papers in PubMed.
- Intensity Variance-Guided Automated Robotic Optical Coherence Tomography System for Ophthalmic Applications.Journal of biophotonics · 2026Article
- Simultaneous OCT A-scan depth ranging and C-scan volume imaging for intraoperative robotic retinal surgery guidance.Biomedical optics express · 2025Article
- Intraoperative Spectrally Encoded Coherence Tomography and Reflectometry (iSECTR) for Ophthalmic Surgical Guidance.Translational vision science & technology · 2025Article
- Clipping spline: interactive, dynamic 4D volume clipping and analysis based on thin plate spline.Biomedical optics express · 2025Article
- New Directions for Ophthalmic OCT - Handhelds, Surgery, and Robotics.Translational vision science & technology · 2025Review
- Emerging Applications of Intraoperative Optical Coherence Tomography in Corneal Surgery: A Narrative Review.Journal of clinical medicine · 2024Review
- Visualization of Cataract Surgery Steps With 4D Microscope-Integrated Swept-Source Optical Coherence Tomography in Ex Vivo Porcine Eyes.Translational vision science & technology · 2024Article
- Molecular and cellular imaging of the eye.Biomedical optics express · 2024Review
- Visualization of surgical maneuvers using intraoperative real-time volumetric optical coherence tomography.Biomedical optics express · 2023Article
- Methods for real-time feature-guided image fusion of intrasurgical volumetric optical coherence tomography with digital microscopy.Biomedical optics express · 2023Article
- Live 4D-OCT denoising with self-supervised deep learning.Scientific reports · 2023Article
- Robotic Optical Coherence Tomography of Human Subjects with Posture-Invariant Head and Eye Alignment in Six Degrees of Freedom.... International Symposium on Medical Robotics. International Symposium on Medical Robotics · 2023Article
- Surgical microscope integrated MHz SS-OCT with live volumetric visualization.Biomedical optics express · 2023Article
- Quantitative measurements of intraocular structures and microinjection bleb volumes using intraoperative optical coherence tomography.Biomedical optics express · 2023Article
- OCT Meets micro-CT: A Subject-Specific Correlative Multimodal Imaging Workflow for Early Chick Heart Development Modeling.Journal of cardiovascular development and disease · 2022Article
- Optical coherence tomography refraction and optical path length correction for image-guided corneal surgery.Biomedical optics express · 2022Article
- Automated instrument-tracking for 4D video-rate imaging of ophthalmic surgical maneuvers.Biomedical optics express · 2022Article
- Real-time OCT image denoising using a self-fusion neural network.Biomedical optics express · 2022Article
- Combined anterior segment OCT and wavefront-based autorefractor using a shared beam.Biomedical optics express · 2021Article
- Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography.Journal of biomedical optics · 2021Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Minimally-invasive microsurgery has resulted in improved outcomes for patients. However, operating through a microscope limits depth perception and fixes the visual perspective, which result in a steep learning curve to achieve microsurgical proficiency. We introduce a surgical imaging system employing four-dimensional (live volumetric imaging through time) microscope-integrated optical coherence tomography (4D MIOCT) capable of imaging at up to 10 volumes per second to visualize human microsurgery. A custom stereoscopic heads-up display provides real-time interactive volumetric feedback to the surgeon. We report that 4D MIOCT enhanced suturing accuracy and control of instrument positioning in mock surgical trials involving 17 ophthalmic surgeons. Additionally, 4D MIOCT imaging was performed in 48 human eye surgeries and was demonstrated to successfully visualize the pathology of interest in concordance with preoperative diagnosis in 93% of retinal surgeries and the surgical site of interest in 100% of anterior segment surgeries. In vivo 4D MIOCT imaging revealed sub-surface pathologic structures and instrument-induced lesions that were invisible through the operating microscope during standard surgical maneuvers. In select cases, 4D MIOCT guidance was necessary to resolve such lesions and prevent post-operative complications. Our novel surgical visualization platform achieves surgeon-interactive 4D visualization of live surgery which could expand the surgeon's capabilities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.