Evidence map›Paper›PMID 27538190›Full record

ArticleCornea2016

Superficial Keratectomy and Conjunctival Advancement Hood Flap (SKCAHF) for the Management of Bullous Keratopathy: Validation in Dogs With Spontaneous Disease.

Taemi Horikawa, Sara M Thomasy, Amelia A Stanley, Allison S Calderon, Jennifer Li, Lana L Linton, Christopher J Murphy

Abstract readValidation Study
In one paragraph

Article in Cornea, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

  1. Diagnostic Ophthalmology.The Canadian veterinary journal = La revue veterinaire canadienne · 2025
    Article
  2. Article
  3. Squishy matters - Corneal mechanobiology in health and disease.Progress in retinal and eye research · 2024
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Diagnostic Ophthalmology.The Canadian veterinary journal = La revue veterinaire canadienne · 2019
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Taemi Horikawa*Animal Eye Center, Rocklin, CA; †Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA; and ‡Department of Ophthalmology and Vision Science, School of Medicine, University of California-Davis, Davis, CA.
Sara M Thomasy
Amelia A Stanley
Allison S Calderon
Jennifer Li
Lana L Linton
Christopher J Murphy
National Institutes of Health · USResearch to Prevent Blindness · USPrevent Blindness · US

Funding

VISION RESEARCH CORE GRANTP30EY012576 · NEI · UNIVERSITY OF CALIFORNIA DAVIS · PI LISA M OAKES · 1999 to 2026
$18.9M
Modulation of Signal Transduction by Nano-TopographyR01EY016134 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI MURPHY, CHRISTOPHER JOHN, THOMASY, SARA MICHELLE · 2006 to 2023
$5.1M
Biophysical Cues and Corneal Wound HealingR01EY019970 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MURPHY, CHRISTOPHER JOHN · 2011 to 2020
$3.5M
Engineering the Corneal Wound Bed to Promote HealingK08EY021142 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI THOMASY, SARA MICHELLE · 2011 to 2015
$879k
NEI NIH HHS K08 EY021142NEI NIH HHS P30 EY012576NEI NIH HHS R01 EY016134NEI NIH HHS R01 EY019970
6 · The paper itself

Abstract

purposeTo evaluate the efficacy of superficial keratectomy and conjunctival advancement hood flap (SKCAHF) for the treatment of bullous keratopathy in canine patients.

methodsNine dogs (12 eyes) diagnosed with progressive corneal edema underwent superficial keratectomy followed by placement of conjunctival advancement hood flaps. The canine patients were examined pre- and postoperatively using in vivo confocal microscopy, ultrasonic pachymetry (USP), and Fourier-domain optical coherence tomography (FD-OCT). All owners responded to a survey regarding treatment outcomes.

resultsMean central corneal thickness (CCT) as measured by FD-OCT was 1163 ± 290 μm preoperatively and significantly decreased postoperatively to 795 ± 197 μm (P = 0.001), 869 ± 190 μm (P = 0.005), and 969 ± 162 μm (P = 0.033) at median postoperative evaluations occurring at 2.2, 6.8, and 12.3 months, respectively. Owners reported significant improvement (P < 0.05) in vision and corneal cloudiness at 6.8 and 12.3 months postoperatively. The percentage of cornea covered by the conjunctival flap was correlated (P = 0.0159) with a reduction in CCT by USP at 12.3 months postoperatively. All canine patients were comfortable pre- and postoperatively.

conclusionsSKCAHF results in a reduction of corneal thickness in canine patients with bullous keratopathy. The increase in corneal thickness over time, after performing SKCAHF, is likely because of progressive endothelial decompensation. This surgery is a potentially effective intervention for progressive corneal edema in dogs that may have value in treatment of human patients with bullous keratopathy.

Indexed as

Surgical FlapsAnimalsBlisterConjunctivaCorneaCorneal EdemaCorneal PachymetryDisease Models, AnimalDog DiseasesDogsFemaleFourier AnalysisMaleMicroscopy, ConfocalTomography, Optical Coherence

Identifiers

PMID27538190
PMCPMC5602554
OpenAlexW2507618868

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.