ArticlePloS one2016
Frailty Index Predicts All-Cause Mortality for Middle-Aged and Older Taiwanese: Implications for Active-Aging Programs.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Frailty and risks of all-cause and cause-specific death in community-dwelling adults: a systematic review and meta-analysis.BMC geriatrics · 2022Pooled it
- Infection trajectories and dementia risk in type 2 diabetes.Diabetology & metabolic syndrome · 2026Article
- Prevalence and impact of frailty on unplanned hospitalizations among adult patients with cancer in Taiwan.The oncologist · 2025Article
- The association between frailty index and all-cause mortality in US individuals with kidney stones: mediation by systemic immune-inflammation (SII) index.Urolithiasis · 2025Article
- Data-driven health deficit assessment improves a frailty index's prediction of current cognitive status and future conversion to dementia: results from ADNI.GeroScience · 2023Article
- Article
- PMScientific reports · 2020Article
- Comparisons Between Hypothesis- and Data-Driven Approaches for Multimorbidity Frailty Index: A Machine Learning Approach.Journal of medical Internet research · 2020Article
- Efficacy of multidomain interventions to improve physical frailty, depression and cognition: data from cluster-randomized controlled trials.Journal of cachexia, sarcopenia and muscle · 2020Article
- Using a genetic algorithm to derive a highly predictive and context-specific frailty index.Aging · 2020Article
- Determinants and indicators of successful ageing associated with mortality: a 4-year population-based study.Aging · 2020Article
- Article
- Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty.Nature communications · 2019Article
- Frailty, transition in frailty status and all-cause mortality in older adults of a Taichung community-based population.BMC geriatrics · 2019Article
- Impact of Health Literacy on Frailty among Community-Dwelling Seniors.Journal of clinical medicine · 2018Article
- The synergic effects of frailty on disability associated with urbanization, multimorbidity, and mental health: implications for public health and medical care.Scientific reports · 2018Article
- Article
- Biological age as a health index for mortality and major age-related disease incidence in Koreans: National Health Insurance Service - Health screening 11-year follow-up study.Clinical interventions in aging · 2018Article
- Article
- Predicting mortality and hospitalization of older adults by the multimorbidity frailty index.PloS one · 2017Article
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6 authors.
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Abstract
backgroundFrailty Index, defined as an individual's accumulated proportion of listed health-related deficits, is a well-established metric used to assess the health status of old adults; however, it has not yet been developed in Taiwan, and its local related structure factors remain unclear. The objectives were to construct a Taiwan Frailty Index to predict mortality risk, and to explore the structure of its factors.
methodsAnalytic data on 1,284 participants aged 53 and older were excerpted from the Social Environment and Biomarkers of Aging Study (2006), in Taiwan. A consensus workgroup of geriatricians selected 159 items according to the standard procedure for creating a Frailty Index. Cox proportional hazard modeling was used to explore the association between the Taiwan Frailty Index and mortality. Exploratory factor analysis was used to identify structure factors and produce a shorter version-the Taiwan Frailty Index Short-Form.
resultsDuring an average follow-up of 4.3 ± 0.8 years, 140 (11%) subjects died. Compared to those in the lowest Taiwan Frailty Index tertile (< 0.18), those in the uppermost tertile (> 0.23) had significantly higher risk of death (Hazard ratio: 3.2; 95% CI 1.9-5.4). Thirty-five items of five structure factors identified by exploratory factor analysis, included: physical activities, life satisfaction and financial status, health status, cognitive function, and stresses. Area under the receiver operating characteristic curves (C-statistics) of the Taiwan Frailty Index and its Short-Form were 0.80 and 0.78, respectively, with no statistically significant difference between them.
conclusionAlthough both the Taiwan Frailty Index and Short-Form were associated with mortality, the Short-Form, which had similar accuracy in predicting mortality as the full Taiwan Frailty Index, would be more expedient in clinical practice and community settings to target frailty screening and intervention.
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