Evidence map›Paper›PMID 27537580›Full record

ArticleMedicine2016

Duloxetine-related posterior reversible encephalopathy syndrome: A case report.

Nathalie Zappella, François Perier, Fernando Pico, Catherine Palette, Alexandre Muret, Sybille Merceron, Andrei Girbovan, Fabien Marquion, Stephane Legriel

Open access · goldAbstract readCase Reports
In one paragraph

Article in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Nathalie ZappellaIntensive Care Unit Neurology and Stroke Department Pharmacology Unit Emergency Department, Centre Hospitalier de Versailles - Site André Mignot, rue de Versailles, Le Chesnay cedex Paris Descartes University, Sorbonne Paris Cité-Medical School INSERM U970, Paris Cardiovascular Research Center, Paris, France.
François Perier
Fernando Pico
Catherine Palette
Alexandre Muret
Sybille Merceron
Andrei Girbovan
Fabien Marquion
Stephane Legriel
Intensive Care Society · GBBrain Physiology Lab · FRCentre Hospitalier de Versailles · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPosterior reversible encephalopathy syndrome (PRES) has well-established links with several drugs. Whether a link also exists with serotonin-norepinephrine reuptake inhibitor such as duloxetine is unclear.

methodsWe report on a patient who developed PRES with a coma and myoclonus related to hypertensive encephalopathy a few days after starting duloxetine treatment. Magnetic resonance imaging was performed and catecholamine metabolites assayed.

resultsThe patient achieved a full recovery after aggressive antihypertensive therapy and intravenous anticonvulsant therapy.

conclusionsThe clinical history, blood and urinary catecholamine and serotonin levels, and response to treatment strongly suggest that PRES was induced by duloxetine. Duloxetine should be added to the list of causes of PRES.

Indexed as

Aged, 80 and overAntidepressive AgentsDepressionDuloxetine HydrochlorideFemaleHumansNeuroimagingPosterior Leukoencephalopathy SyndromeTomography, X-Ray ComputedAntidepressive AgentsDuloxetine Hydrochloride

Identifiers

PMID27537580
PMCPMC5370806
OpenAlexW2517410172

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.