ArticlePloS one2016
Reproduction Does Not Adversely Affect Liver Mitochondrial Respiratory Function but Results in Lipid Peroxidation and Increased Antioxidants in House Mice.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- The cell origin of reactive oxygen species and its implication for evolutionary trade-offs.Open biology · 2025Review
- Mitochondrial physiology varies with parity and body mass in the laboratory mouse (Mus musculus).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- Effect of acute nitrite infusion on contractile economy and metabolism in isolated skeletal muscle in situ during hypoxia.The Journal of physiology · 2020Article
- Exercise Training Prevents Doxorubicin-induced Mitochondrial Dysfunction of the Liver.Medicine and science in sports and exercise · 2019Article
- Changes in Metabolism, Mitochondrial Function, and Oxidative Stress Between Female Rats Under Nonreproductive and 3 Reproductive Conditions.Reproductive sciences (Thousand Oaks, Calif.) · 2019Article
- Cellular metabolic rates and oxidative stress profiles in primary fibroblast cells isolated from virgin females, reproductively experienced females, and male Sprague-Dawley rats.Physiological reports · 2018Article
- Life History Trade-offs within the Context of Mitochondrial Hormesis.Integrative and comparative biology · 2018Review
- High activity before breeding improves reproductive performance by enhancing mitochondrial function and biogenesis.The Journal of experimental biology · 2018Article
- Physiological, mitochondrial, and oxidative stress differences in the presence or absence of lactation in rats.Reproductive biology and endocrinology : RB&E · 2018Article
- A mitohormetic response to pro-oxidant exposure in the house mouse.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Lactation has persistent effects on a mother's metabolism and mitochondrial function.Scientific reports · 2017Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Reproduction is thought to come at a cost to longevity. Based on the assumption that increased energy expenditure during reproduction is associated with increased free-radical production by mitochondria, oxidative damage has been suggested to drive this trade-off. We examined the impact of reproduction on liver mitochondrial function by utilizing post-reproductive and non-reproductive house mice (Mus musculus) living under semi-natural conditions. The age-matched post-reproductive and non-reproductive groups were compared after the reproductive females returned to a non-reproductive state, so that both groups were in the same physiological state at the time the liver was collected. Despite increased oxidative damage (p = 0.05) and elevated CuZnSOD (p = 0.002) and catalase (p = 0.04) protein levels, reproduction had no negative impacts on the respiratory function of liver mitochondria. Specifically, in a post-reproductive, maintenance state the mitochondrial coupling (i.e., respiratory control ratio) of mouse livers show no negative impacts of reproduction. In fact, there was a trend (p = 0.059) to suggest increased maximal oxygen consumption by liver mitochondria during the ADP stimulated state (i.e., state 3) in post-reproduction. These findings suggest that oxidative damage may not impair mitochondrial respiratory function and question the role of mitochondria in the trade-off between reproduction and longevity. In addition, the findings highlight the importance of quantifying the respiratory function of mitochondria in addition to measuring oxidative damage.
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Registered trials
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