ArticlePloS one2016
Rickettsial Infections among Ctenocephalides felis and Host Animals during a Flea-Borne Rickettsioses Outbreak in Orange County, California.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 68 citations in OpenAlex.
- Phylogenetic, genomic and morphological characterization ofInternational journal of systematic and evolutionary microbiology · 2026Article
- Outcomes of Hospitalized and Critically Ill Adults with Murine Typhus, Galveston, Texas, USA, 2019-2023.Emerging infectious diseases · 2026Review
- Organ Donor Transmission of Rickettsia typhi to Kidney Transplant Recipients, Texas, USA, 2024.Emerging infectious diseases · 2025Article
- Oral Flea Preventive to Control Rickettsia typhi-Infected Fleas on Reservoir Opossums, Galveston, Texas, USA, 2023-2024.Emerging infectious diseases · 2025Article
- A One Health Perspective on the Resurgence of Flea-Borne Typhus in Texas in the 21st Century: Part 1: The Bacteria, the Cat Flea, Urbanization, and Climate Change.Pathogens (Basel, Switzerland) · 2025Article
- Dog ectoparasites as sentinels for pathogenic Rickettsia and Bartonella in rural Guatemala.Acta tropica · 2024Article
- Duplex Reverse-Transcription Real-Time Polymerase Chain Reaction Assay Targeting 23S rRNA Single Nucleotide Polymorphisms for the Detection of Flea-Borne Rickettsioses.The American journal of tropical medicine and hygiene · 2024Article
- Dog ectoparasites as sentinels for pathogenic Rickettsia and Bartonella in rural Guatemala.Research square · 2024Article
- Cat Flea Coinfection withVector borne and zoonotic diseases (Larchmont, N.Y.) · 2024Article
- Murine Typhus: A Review of a Reemerging Flea-Borne Rickettsiosis with Potential for Neurologic Manifestations and Sequalae.Infectious disease reports · 2023Review
- Epidemiological Study of the Occurrence of Typhus GroupAnimals : an open access journal from MDPI · 2022Article
- Review
- Didelphis spp. opossums and their parasites in the Americas: A One Health perspective.Parasitology research · 2021Review
- Unpacking the intricacies of Rickettsia-vector interactions.Trends in parasitology · 2021Review
- Amplicon-Based Next Generation Sequencing for Rapid Identification ofPathogens (Basel, Switzerland) · 2021Article
- Parasites of Native and Invasive Rodents in Chile: Ecological and Human Health Needs.Frontiers in veterinary science · 2021Review
- Screening of ectoparasites from domesticated dogs for bacterial pathogens in Vientiane, Lao PDR.Zoonoses and public health · 2020Article
- Metagenomic analysis of human-biting cat fleas in urban northeastern United States of America reveals an emerging zoonotic pathogen.Scientific reports · 2020Article
- Serosurvey of IgG Antibodies againstTropical medicine and infectious disease · 2020Article
- Role of vector-borne pathogens in the development of fever in cats: 1. Flea-associated diseases.Journal of feline medicine and surgery · 2020Review
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
Due to a resurgence of flea-borne rickettsioses in Orange County, California, we investigated the etiologies of rickettsial infections of Ctenocephalides felis, the predominant fleas species obtained from opossums (Didelphis virginiana) and domestic cats (Felis catus), collected from case exposure sites and other areas in Orange County. In addition, we assessed the prevalence of IgG antibodies against spotted fever group (SFGR) and typhus group (TGR) rickettsiae in opossum sera. Of the 597 flea specimens collected from opossums and cats, 37.2% tested positive for Rickettsia. PCR and sequencing of rickettsial genes obtained from C. felis flea DNA preparations revealed the presence of R. typhi (1.3%), R. felis (28.0%) and R. felis-like organisms (7.5%). Sera from opossums contained TGR-specific (40.84%), but not SFGR-specific antibodies. The detection of R. felis and R. typhi in the C. felis fleas in Orange County highlights the potential risk for human infection with either of these pathogens, and underscores the need for further investigations incorporating specimens from humans, animal hosts, and invertebrate vectors in endemic areas. Such studies will be essential for establishing a link in the ongoing flea-borne rickettsioses outbreaks.
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Registered trials
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