ArticlePloS one2016
Inflammation as a Risk of Developing Chronic Kidney Disease in Rheumatoid Arthritis.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 64 citations in OpenAlex.
- Amelioration of experimentally induced-arthritis by guaiazulene through targeting inflammatory and oxidative stress biomarkers in Wistar rat.Inflammopharmacology · 2026Article
- Renal Vascular Involvement Assessed by Intrarenal Resistive Index in Patients with Rheumatoid Arthritis: Associations with Structural Joint Damage and Cardiovascular Risk.Journal of clinical medicine · 2026Article
- The Interplay Between Rheumatoid Arthritis and Chronic Kidney Disease: From Mechanisms to Treatment.Journal of clinical medicine · 2025Review
- Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis.Advanced healthcare materials · 2025Review
- Prevalence and Pathogenetic Mechanisms of Chronic Kidney Disease in Autoimmune-Mediated Systemic Diseases.Journal of clinical medicine research · 2025Review
- Novel Dietary Inflammatory Score and Risk of Incident CKD.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- Disease activity of rheumatoid arthritis and kidney function decline: a large prospective registry study.Annals of the rheumatic diseases · 2025Article
- Kidney damage associated with COVID-19: from the acute to the chronic phase.Renal failure · 2024Review
- Infectious and Commensal Bacteria in Rheumatoid Arthritis-Role in the Outset and Progression of the Disease.International journal of molecular sciences · 2024Review
- Oxidative balance score and the potential for suffering rheumatoid arthritis: a cross-sectional study.Frontiers in immunology · 2024Article
- Rheumatoid arthritis and the risk of chronic kidney diseases: a Mendelian randomization study.Frontiers in medicine · 2024Article
- The Association of Kidney Function and Inflammatory Biomarkers with Epithelial Ovarian Cancer Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023Article
- Associations ofGenes · 2023Article
- Commentary: Rheumatoid arthritis and the risk of end-stage renal disease: a nationwide, population-based study.Frontiers in medicine · 2023Article
- Sex differences in long-term effects of collagen-induced arthritis in middle-aged mice.Frontiers in physiology · 2023Article
- The effect of targeted rheumatoid arthritis therapeutics on systemic inflammation and anemia: analysis of data from the CorEvitas RA registry.Arthritis research & therapy · 2022Article
- The Association Between Dietary Acidity and Clinical Symptoms in Patients With Rheumatoid Arthritis.Clinical nutrition research · 2022Article
- Decreased chronic kidney disease in rheumatoid arthritis in the era of biologic disease-modifying anti-rheumatic drugs.Clinical kidney journal · 2022Article
- Evaluating the Use of Hydroxychloroquine in Treating Patients With Rheumatoid Arthritis.Cureus · 2021Review
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Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe relationship between chronic inflammation and the incidence of chronic kidney disease (CKD) remained not-clear in patients with rheumatoid arthritis (RA). This study aims to examine the relationship between persistently high C-reactive protein (CRP), a marker of inflammation, and the incidence of CKD in RA.
methodsWe retrospectively examined the relationship between the levels of CRP and incidence of CKD in 345 RA patients. The outcome of interest was incidence of CKD, defined as an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 and/or positive dipstick testing for proteinuria for ≥3 months. We defined high CRP, as >3.0 mg/L. On the basis of three measurements of CRP for 6-months period, patients were divided into three groups: group 1, including patients with no high CRP values; group 2, patients with transient high CRP values (once or twice) and group 3, patients with persistently high CRP values.
resultsDuring a median follow-up period of 89 months, 14% of all patients developed CKD. The cumulative incidence of CKD was 7% in group 1, 14% in group 2 and 22% in group 3 (P = 0.008, log-rank test). In a multivariate analysis, including classical risk factors for CKD, persistently high CRP was an independent predictor of the incidence of CKD (hazard ratio, 3.00; 95% confidence interval, 1.23-8.53; P = 0.01).
conclusionsPersistently high CRP was a significant risk factor for the incidence of CKD. Results suggest that persistent inflammation is a marker for the high risk of CKD in RA.
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