Evidence map›Paper›PMID 27537196›Full record

ArticlePrion2016

Intra-host mathematical model of chronic wasting disease dynamics in deer (Odocoileus).

Karen M Holcomb, Nathan L Galloway, Candace K Mathiason, Michael F Antolin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Prion, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. The ecology of chronic wasting disease in wildlife.Biological reviews of the Cambridge Philosophical Society · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Karen M Holcomba Department of Biology , Colorado State University , Fort Collins , CO , USA.
Nathan L Gallowaya Department of Biology , Colorado State University , Fort Collins , CO , USA.
Candace K Mathiasonb Department of Microbiology , Immunology, and Pathology, Colorado State University , Fort Collins , CO , USA.
Michael F Antolina Department of Biology , Colorado State University , Fort Collins , CO , USA.
Colorado State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bioassays of native cervid hosts have established the presence of infectious chronic wasting disease (CWD) prions in saliva, blood, urine, and feces of clinically diseased and pre-clinical infected deer. The intra-host trafficking of prions from the time of initial infection to shedding has been less well defined. We created a discrete-time compartmentalized model to simulate the misfolding catalysis, trafficking, and shedding of infectious prions throughout the organ systems of CWD-infected cervids. Using parameter values derived from experimental infections of North American deer (Odocoileus spp.), the exponential-based model predicts prion deposition over time with: 1) nervous tissues containing the highest deposition of prions at 20 months post-infection and 2) excreted fluids containing low levels of prions throughout infection with the highest numbers of prions predicted to be shed in saliva and feces (as high as 10 lethal doses (1.34 × 10

Indexed as

DeerModels, StatisticalAnimalsBody FluidsFecesPrionsSensitivity and SpecificityWasting Disease, ChronicPrionschronic wasting diseaseenvironmental sheddinghorizontal transmissionprionRT-QuICsPMCAwestern blotwithin-host disease dynamics

Identifiers

PMID27537196
PMCPMC5105936
OpenAlexW2508867150

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.