ArticleeLife2016
Stochastic and deterministic dynamics of intrinsically irregular firing in cortical inhibitory interneurons.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Statistical learning of stochastic complex systems via the Yau-Yau nonlinear filter.Innovation (Cambridge (Mass.)) · 2026Article
- Naturalizing perceptual experience: the explanatory power of probabilistic computation and the holographic solution.Frontiers in human neuroscience · 2026Article
- Neuronal Electrical Activity in Neuronal Networks Induced by a Focused Femtosecond Laser.ACS omega · 2025Article
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- Learning interpretable dynamics of stochastic complex systems from experimental data.Nature communications · 2024Article
- The Constrained Disorder Principle May Account for Consciousness.Brain sciences · 2024Review
- A universal workflow for creation, validation, and generalization of detailed neuronal models.Patterns (New York, N.Y.) · 2023Article
- Recurrence-Based Synchronization Analysis of Weakly Coupled Bursting Neurons under External ELF Fields.Entropy (Basel, Switzerland) · 2022Article
- A dopamine gradient controls access to distributed working memory in the large-scale monkey cortex.Neuron · 2021Article
- Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity.Molecular psychiatry · 2021Article
- Characterizing the brain's dynamical response from scalp-level neural electrical signals: a review of methodology development.Cognitive neurodynamics · 2020Review
- Chronic mild stress alters synaptic plasticity in the nucleus accumbens through GSK3β-dependent modulation of Kv4.2 channels.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Persistent sodium current blockers can suppress seizures caused by loss of low-threshold D-type potassium currents: Predictions from an in silico study of KEpilepsia open · 2020Article
- Cortical reliability amid noise and chaos.Nature communications · 2019Article
- Kv4.2 channel activity controls intrinsic firing dynamics of arcuate kisspeptin neurons.The Journal of physiology · 2018Article
- Kv4 channels to kisspeptin neurons: 'Let's (not) go steady'.The Journal of physiology · 2018Article
- Article
- Functional Diversity of Neurotrophin Actions on the Oculomotor System.International journal of molecular sciences · 2016Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Most cortical neurons fire regularly when excited by a constant stimulus. In contrast, irregular-spiking (IS) interneurons are remarkable for the intrinsic variability of their spike timing, which can synchronize amongst IS cells via specific gap junctions. Here, we have studied the biophysical mechanisms of this irregular spiking in mice, and how IS cells fire in the context of synchronous network oscillations. Using patch-clamp recordings, artificial dynamic conductance injection, pharmacological analysis and computational modeling, we show that spike time irregularity is generated by a nonlinear dynamical interaction of voltage-dependent sodium and fast-inactivating potassium channels just below spike threshold, amplifying channel noise. This active irregularity may help IS cells synchronize with each other at gamma range frequencies, while resisting synchronization to lower input frequencies.
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