ArticleJournal of gerontology & geriatric research2015
Leptin, Adiponectin and Cognition in Middle-aged HIV-infected and Uninfected Women. The Brooklyn Women's Interagency HIV Study.
Article in Journal of gerontology & geriatric research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Serum NFL and neuropsychological performance over ∼8 years in women with and without HIV: a longitudinal repeated measures study.EClinicalMedicine · 2025Article
- Plasma Biomarkers of Alzheimer Disease in Women With and Without HIV.JAMA network open · 2023Article
- Body Mass Index and Leptin Are Related to Cognitive Performance Over 10 Years in Women With and Without HIV Infection.The Journal of clinical endocrinology and metabolism · 2022Observational
- High baseline body mass index predicts recovery of CD4+ T lymphocytes for HIV/AIDS patients receiving long-term antiviral therapy.PloS one · 2022Article
- Article
- Obesity, Vascular Disease and Frailty in Aging Women with HIV.Advances in geriatric medicine and research · 2021Article
- Commentary on Lahiri et al. Weight and Body Mass Index Change After Switching to Integrase Inhibitors or Tenofovir Alafenamide Among Women Living with HIV.Journal of AIDS and HIV treatment · 2021Article
- Neurocognitive Inhibitory Control Ability Performance and Correlations with Biochemical Markers in Obese Women.International journal of environmental research and public health · 2020Article
- Epidemiology Informs Randomized Clinical Trials of Cognitive Impairments and Late-Onset, Sporadic Dementias.Journal of neurology & neuromedicine · 2018Article
- The Fat of the Matter: Obesity and Visceral Adiposity in Treated HIV Infection.Current HIV/AIDS reports · 2017Review
- Ghrelin, Amylin, Gastric Inhibitory Peptide and Cognition in Middle-Aged HIV-Infected and Uninfected Women: The Women's Interagency HIV Study.Journal of neurology & neurophysiology · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
contextCase-control study of women with and without HIV infection.
objectiveTo explore the association of cognition and the adipokines, leptin and adiponectin (total; high molecular weight, HMW), in women with (HIV+) and without HIV (HIV-) infection.
designCross-sectional analyses of adipokines and cognition using linear regression models of log-transformed adipokines, and Trails A, Trails B, Stroop interference time, Stroop word recall, Stroop color naming and reading, and Symbol Digit Modalities Test (SDMT) with consideration for age, HIV infection status, education, CD4 count, diabetes, body mass index (BMI), waist circumference (WC) and race/ethnicity.
settingBrooklyn, NY.
participants354 participants (247 HIV+, 107 HIV-), in the Brooklyn Women's Interagency HIV Study (WIHS), average age 38.9 years, with measured levels of leptin and adiponectin (total and high molecular weight, HMW).
main outcome measureCognition.
resultsHigher levels of leptin were positively associated with worse cognition on the basis of Trails A completion time and SDMT score. Among at risk HIV- women, leptin was associated with worse performance on Trails B. No associations were observed for total or HMW adiponectin.
conclusionBlood adipokine levels were measured to provide mechanistic insights regarding the association of adipose with cognitive function. These data suggest that higher levels of leptin, consistent with more adipose tissue, are associated with worse cognitive function in middle age. Monitoring leptin over time and with increasing age in relation to cognition and dementia, may lend insights to the role of adipose tissue in successful body and brain aging among women with HIV infection.
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