ArticleAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology2016
Antibiotic prescription and food allergy in young children.
Article in Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Risk Factors for the Development of Food Allergy in Infants and Children: A Systematic Review and Meta-Analysis.JAMA pediatrics · 2026Pooled it
- Antibiotic prescribing in inpatient and outpatient settings in Iran: a systematic review and meta-analysis study.Antimicrobial resistance and infection control · 2021Pooled it
- Prenatal and Early-Life Exposure to Microbiome-Modulating Medications and the Risk of Childhood Food Allergy: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Association of Acid-Suppressive Medication and Antimicrobial Use in Infancy with Food Allergy and Anaphylaxis.Journal of clinical medicine · 2025Article
- A web-based questionnaire to evaluate risk factors to develop cow milk allergy.European journal of pediatrics · 2025Article
- Maternal influences on offspring food allergy.Immunological reviews · 2024Review
- ProbResist: a database for drug-resistant probiotic bacteria.Database : the journal of biological databases and curation · 2022Article
- Importance of crosstalk between the microbiota and the neuroimmune system for tissue homeostasis.Clinical & translational immunology · 2022Review
- Antibiotic-Induced Gut Microbiota Dysbiosis Damages the Intestinal Barrier, Increasing Food Allergy in Adult Mice.Nutrients · 2021Article
- Diversity of Microbial Signatures in Asthmatic Airways.International journal of general medicine · 2021Review
- Article
- Regulatory T Cells Developing Peri-Weaning Are Continually Required to Restrain Th2 Systemic Responses Later in Life.Frontiers in immunology · 2020Article
- [Risk factors for cow's milk protein allergy in infants: a multicenter survey].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Article
- The gut microbiota, environmental factors, and links to the development of food allergy.Clinical and molecular allergy : CMA · 2020Review
- Phage Therapy with a Focus on the Human Microbiota.Antibiotics (Basel, Switzerland) · 2019Review
- Microbiota and Food Allergy.Clinical reviews in allergy & immunology · 2019Review
- Inherited nongenetic influences on the gut microbiome and immune system.Birth defects research · 2018Review
- Advances in optimizing the prescription of antibiotics in outpatient settings.BMJ (Clinical research ed.) · 2018Review
- Development of Immune Cells in the Intestinal Mucosa Can Be Affected by Intensive and Extensive Farm Environments, and Antibiotic Use.Frontiers in immunology · 2018Article
- Early Infant Feeding Practices as Possible Risk Factors for Immunoglobulin E-Mediated Food Allergies in Kuwait.International journal of pediatrics · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo assess the relationship between any systemic antibiotic prescription within the first year of life and the presence of an ICD-9-CM diagnosis code for food allergy (FA).
methodsThis was a matched case-control study conducted using South Carolina Medicaid administrative data. FA cases born between 2007 and 2009 were matched to controls without FA on birth month/year, sex, race/ethnicity. Conditional logistic regression was used to model the adjusted odds ratio (aOR) of FA diagnosis. All models were adjusted for presence of asthma, wheeze, or atopic dermatitis.
resultsA total of 1504 cases and 5995 controls were identified. Receipt of an antibiotic prescription within the initial 12 months of life was associated with FA diagnosis in unadjusted and adjusted models (aOR 1.21; 95 % CI 1.06-1.39). Compared to children with no antibiotic prescriptions, a linear increase in the aOR was seen with increasing antibiotic prescriptions. Children receiving five or more (aOR 1.64; 95 % CI 1.31-2.05) antibiotic prescriptions were significantly associated with FA diagnosis. The strongest association was noted among recipients of cephalosporin and sulfonamide antibiotics in both unadjusted and adjusted models.
conclusionsReceipt of antibiotic prescription in the first year of life is associated with FA diagnosis code in young children after controlling for common covariates. Multiple antibiotic prescriptions are more strongly associated with increases in the odds of FA diagnosis.
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