ArticleFrontiers in physiology2016
Expression of Nerve Growth Factor (NGF), TrkA, and p75(NTR) in Developing Human Fetal Teeth.
Article in Frontiers in physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Single-cell analysis of ecto-mesenchymal cells derived from the neural crest reveals the regulatory role of P75NTR in odontogenic and osteogenic differentiation.BMC oral health · 2025Article
- Single cell RNA sequencing reveals mesenchymal heterogeneity and critical functions ofWorld journal of stem cells · 2023Article
- Neural Regeneration in Regenerative Endodontic Treatment: An Overview and Current Trends.International journal of molecular sciences · 2022Review
- Neural Regulations in Tooth Development and Tooth-Periodontium Complex Homeostasis: A Literature Review.International journal of molecular sciences · 2022Review
- [Nerve growth factor combined with dental pulp stem cells promotes peri-implant osseointegration in rats].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021Article
- Temporo-spatial distribution of stem cell markers CD146 and p75NTR during odontogenesis in mice.Journal of applied oral science : revista FOB · 2021Article
- The Versatile Roles of Nerve Growth Factor in Neuronal Attraction, Odontoblast Differentiation, and Mineral Deposition in Human Teeth.Advances in experimental medicine and biology · 2021Article
- Immunohistochemical Detection of Nerve Growth Factor (NGF) in Follicular and Plexiform Ameloblastoma - A Novel Study.Journal of pharmacy & bioallied sciences · 2020Article
- Aging and Senescence of Dental Pulp and Hard Tissues of the Tooth.Frontiers in cell and developmental biology · 2020Review
- Dental Pulp Stem Cells: Advances to Applications.Stem cells and cloning : advances and applications · 2020Review
- Mouse Nerve Growth Factor Facilitates the Growth of Interspinal Schwannoma Cells by Activating NGF Receptors.Journal of Korean Neurosurgical Society · 2019Article
- Tuftelin Is Required for NGF-Induced Differentiation of PC12 Cells.Journal of molecular neuroscience : MN · 2019Article
- The spatiotemporal expression and mineralization regulation of p75 neurotrophin receptor in the early tooth development.Cell proliferation · 2019Article
- Schwann Cell Responses and Plasticity in Different Dental Pulp Scenarios.Frontiers in cellular neuroscience · 2018Review
- Nerve growth factor signalling in pathology and regeneration of human teeth.Scientific reports · 2017Article
- Immunohistochemical analysis of Nuclear Factor-kappa B (NF-κB) between follicular and plexiform ameloblastomas: A pilot study.Journal of oral and maxillofacial pathology : JOMFPArticle
- Immunohistochemical detection of Tyrosine Kinase receptor (TrK) in follicular and plexiform ameloblastoma - A novel study.Journal of oral and maxillofacial pathology : JOMFPArticle
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2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nerve growth factor (NGF) is important for the development and the differentiation of neuronal and non-neuronal cells. NGF binds to specific low- and high-affinity cell surface receptors, respectively, p75(NTR) and TrkA. In the present study, we examined by immunohistochemistry the expression patterns of the NGF, p75(NTR), and TrkA proteins during human fetal tooth development, in order to better understand the mode of NGF signaling action in dental tissues. The results obtained show that these molecules are expressed in a wide range of dental cells of both epithelial and mesenchymal origin during early stages of odontogenesis, as well as in nerve fibers that surround the developing tooth germs. At more advanced developmental stages, NGF and TrkA are localized in differentiated cells with secretory capacities such as preameloblasts/ameloblasts secreting enamel matrix and odontoblasts secreting dentine matrix. In contrast, p75(NTR) expression is absent from these secretory cells and restricted in proliferating cells of the dental epithelium. The temporospatial distribution of NGF and p75(NTR) in fetal human teeth is similar, but not identical, with that observed previously in the developing rodent teeth, thus indicating that the genetic information is well-conserved during evolution. The expression patterns of NGF, p75(NTR), and TrkA during odontogenesis suggest regulatory roles for NGF signaling in proliferation and differentiation of epithelial and mesenchymal cells, as well as in attraction and sprouting of nerve fibers within dental tissues.
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