Evidence map›Paper›PMID 27536241›Full record

ReviewFrontiers in pharmacology2016

MSCs-Derived Exosomes: Cell-Secreted Nanovesicles with Regenerative Potential.

Ana Marote, Fábio G Teixeira, Bárbara Mendes-Pinheiro, António J Salgado

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 172 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
172citing papers in PubMed, 4 pooled it
15.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

172 citing papers in PubMed, 4 syntheses or guidelines pooled it, 288 citations in OpenAlex.

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112 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ana MaroteLife and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, BragaPortugal; ICVS/3B's, PT Government Associate Laboratory, Braga/GuimarãesPortugal.
Fábio G TeixeiraLife and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, BragaPortugal; ICVS/3B's, PT Government Associate Laboratory, Braga/GuimarãesPortugal.
Bárbara Mendes-PinheiroLife and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, BragaPortugal; ICVS/3B's, PT Government Associate Laboratory, Braga/GuimarãesPortugal.
António J SalgadoLife and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, BragaPortugal; ICVS/3B's, PT Government Associate Laboratory, Braga/GuimarãesPortugal.
University of Minho · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes are membrane-enclosed nanovesicles (30-150 nm) that shuttle active cargoes between different cells. These tiny extracellular vesicles have been recently isolated from mesenchymal stem cells (MSCs) conditioned medium, a population of multipotent cells identified in several adult tissues. MSCs paracrine activity has been already shown to be the key mediator of their elicited regenerative effects. On the other hand, the individual contribution of MSCs-derived exosomes for these effects is only now being unraveled. The administration of MSCs-derived exosomes has been demonstrated to restore tissue function in multiple diseases/injury models and to induce beneficial in vitro effects, mainly mediated by exosomal-enclosed miRNAs. Additionally, the source and the culture conditions of MSCs have been shown to influence the regenerative responses induced by exosomes. Therefore, these studies reveal that MSCs-derived exosomes hold a great potential for cell-free therapies that are safer and easier to manipulate than cell-based products. Nevertheless, this is an emerging research field and hence, further studies are required to understand the full dimension of this complex intercellular communication system and how it can be optimized to take full advantage of its therapeutic effects. In this mini-review, we summarize the most significant new advances in the regenerative properties of MSCs-derived exosomes and discuss the molecular mechanisms underlying these effects.

Indexed as

cell-free therapyexosomesmesenchymal stem cellsregenerationsecretome

Identifiers

PMID27536241
PMCPMC4971062
OpenAlexW2480584347

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.