ArticleFrontiers in human neuroscience2016
Altered Brain Microstate Dynamics in Adolescents with Narcolepsy.
Article in Frontiers in human neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 36 papers, 2 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Utilization of EEG microstates as a prospective biomarker for assessing the impact of ketogenic diet in GLUT1-DS.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- The Functional Aspects of Resting EEG Microstates: A Systematic Review.Brain topography · 2024Pooled it
- Dynamic Brain State Alterations in Narcolepsy: A Hidden Markov Model Approach to Thalamocortical Instability and Symptom-Specific Neural Correlates.Brain and behavior · 2026Article
- Orexin effect on physiological pulsations of the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- White matter integrity in narcolepsy: the structural blueprint for functional complaints?Sleep · 2024Article
- Frequency Analysis of EEG Microstate Sequences in Wakefulness and NREM Sleep.Brain topography · 2024Article
- Characterization of the Increase in Narcolepsy following the 2009 H1N1 Pandemic in Sweden.Journal of clinical medicine · 2024Article
- Article
- A comprehensive prediction model of drug-refractory epilepsy based on combined clinical-EEG microstate features.Therapeutic advances in neurological disorders · 2024Article
- All-night spectral and microstate EEG analysis in patients with recurrent isolated sleep paralysis.Frontiers in neuroscience · 2024Article
- RSBagging: An ensemble classifier detecting the after-effects of ischemic stroke through EEG connectivity and microstates.PloS one · 2024Article
- Study on tinnitus-related electroencephalogram microstates in patients with vestibular schwannomas.Frontiers in neuroscience · 2023Article
- EEG spectral and microstate analysis originating residual inhibition of tinnitus induced by tailor-made notched music training.Frontiers in neuroscience · 2023Article
- Dynamic Changes of Brain Activity in Different Responsive Groups of Patients with Prolonged Disorders of Consciousness.Brain sciences · 2022Article
- Narcolepsy-A Neuropathological Obscure Sleep Disorder: A Narrative Review of Current Literature.Brain sciences · 2022Review
- Canonical EEG microstates transitions reflect switching among BOLD resting state networks and predict fMRI signal.Journal of neural engineering · 2022Article
- Increased very low frequency pulsations and decreased cardiorespiratory pulsations suggest altered brain clearance in narcolepsy.Communications medicine · 2022Article
- Resting-State EEG Microstates Parallel Age-Related Differences in Allocentric Spatial Working Memory Performance.Brain topography · 2021Article
- Hypothalamus and amygdala functional connectivity at rest in narcolepsy type 1.NeuroImage. Clinical · 2021Article
- Simultaneous Assessment of Electroencephalography Microstates and Resting State Intrinsic Networks in Alzheimer's Disease and Healthy Aging.Frontiers in neurology · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Narcolepsy is a chronic sleep disorder caused by a loss of hypocretin-1 producing neurons in the hypothalamus. Previous neuroimaging studies have investigated brain function in narcolepsy during rest using positron emission tomography (PET) and single photon emission computed tomography (SPECT). In addition to hypothalamic and thalamic dysfunction they showed aberrant prefrontal perfusion and glucose metabolism in narcolepsy. Given these findings in brain structure and metabolism in narcolepsy, we anticipated that changes in functional magnetic resonance imaging (fMRI) resting state network (RSN) dynamics might also be apparent in patients with narcolepsy. The objective of this study was to investigate and describe brain microstate activity in adolescents with narcolepsy and correlate these to RSNs using simultaneous fMRI and electroencephalography (EEG). Sixteen adolescents (ages 13-20) with a confirmed diagnosis of narcolepsy were recruited and compared to age-matched healthy controls. Simultaneous EEG and fMRI data were collected during 10 min of wakeful rest. EEG data were analyzed for microstates, which are discrete epochs of stable global brain states obtained from topographical EEG analysis. Functional MRI data were analyzed for RSNs. Data showed that narcolepsy patients were less likely than controls to spend time in a microstate which we found to be related to the default mode network and may suggest a disruption of this network that is disease specific. We concluded that adolescents with narcolepsy have altered resting state brain dynamics.
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