ArticleCentral-European journal of immunology2016
Association of the polymorphisms of TRAF1 (rs10818488) and TNFAIP3 (rs2230926) with rheumatoid arthritis and systemic lupus erythematosus and their relationship to disease activity among Egyptian patients.
Article in Central-European journal of immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Interactions between TNFAIP3, PTPN22, and TRAF1-C5 gene polymorphisms in patients with primary Sjögren's syndrome.Archives of rheumatology · 2024Article
- Article
- No association of eight TNFAIP3 single nucleotide variants to rheumatoid arthritis in Mexicans.Molecular biology reports · 2022Article
- Molecular biology of autoinflammatory diseases.Inflammation and regeneration · 2021Review
- Alterations and abnormal expression of A20 in peripheral monocyte subtypes in patients with rheumatoid arthritis.Clinical rheumatology · 2021Article
- A De Novo Frameshift Mutation in TNFAIP3 Impairs A20 Deubiquitination Function to Cause Neuropsychiatric Systemic Lupus Erythematosus.Journal of clinical immunology · 2019Article
- Methotrexate treatment efficacy in sarcoidosis might be related to TNF-α polymorphism: real life preliminary study.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2019Article
- Associations ofCentral-European journal of immunology · 2019Article
- Mir-483 inhibits colon cancer cell proliferation and migration by targeting TRAF1.The Kaohsiung journal of medical sciences · 2018Article
- An Autoimmune Disease-Associated Risk Variant in theJournal of clinical microbiology · 2018Article
- A20/Tumor Necrosis Factor α-Induced Protein 3 in Immune Cells Controls Development of Autoinflammation and Autoimmunity: Lessons from Mouse Models.Frontiers in immunology · 2018Review
- Updates in Lupus Genetics.Current rheumatology reports · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aim of the studyRecent studies demonstrated the association of tumor necrosis factor α-induced protein 3 (TNFAIP3) (rs2230926) and tumor necrosis factor receptor associated factor 1 (TRAF1) (rs10818488) with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in different populations. We aimed at determining whether they confer susceptibility to SLE and RA in Egyptian population and if there is any relation to disease activity and auto-antibodies profile. MATERIAL AND
methodsA case-control study involving 105 individuals with RA, 90 with SLE and 75 healthy controls was performed using TaqMan genotyping assay for two SNPs that showed the best evidence of association in the previous Caucasian studies.
resultsWe detected significant differences in G allele frequency of TNFAIP3 (rs2230926) with SLE (p = 0.017(*)) and RA (OR = 2.333; 95% CI: 1.103-4.935, p = 0.023(*)) and association with RA disease activity (< 0.001). The A allele of TRAF1 was significantly increased in RA compared to controls(p = 0.049) and with RA activity (p = 0.001), while TRAF1 polymorphism did not exhibit any significant difference in the frequencies of genotypes or alleles in SLE and control (p = 0.280).
conclusionsTNFAIP3 is a susceptibility gene to SLE and RA in the Egyptian population and is correlated to disease activity and the presence of autoantibodies while TRAF1 polymorphisms increase the risk of RA but not to SLE in Egyptian populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.