ArticleInternational journal of chronic obstructive pulmonary disease2016
A size-based emphysema severity index: robust to the breath-hold-level variations and correlated with clinical parameters.
Article in International journal of chronic obstructive pulmonary disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- Preliminary Results of Developing Imaging Complexity Biomarkers for the Incidence of Severe Radiation Pneumonitis Following Radiotherapy in Non-Small Cell Lung Cancer Patients with Underlying Idiopathic Pulmonary Fibrosis.Life (Basel, Switzerland) · 2024Article
- Evaluation of retrieval accuracy and visual similarity in content-based image retrieval of chest CT for obstructive lung disease.Scientific reports · 2024Article
- Radiomics approach for survival prediction in chronic obstructive pulmonary disease.European radiology · 2021Article
- Fractal Analysis of Lung Structure in Chronic Obstructive Pulmonary Disease.Frontiers in physiology · 2020Review
- Low morphometric complexity of emphysematous lesions predicts survival in chronic obstructive pulmonary disease patients.European radiology · 2019Article
- Size variation and collapse of emphysema holes at inspiration and expiration CT scan: evaluation with modified length scale method and image co-registration.International journal of chronic obstructive pulmonary disease · 2017Article
- Asynchrony in respiratory movements between the pulmonary lobes in patients with COPD: continuous measurement of lung density by 4-dimensional dynamic-ventilation CT.International journal of chronic obstructive pulmonary disease · 2017Article
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7 authors.
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Abstract
objectiveTo determine the power-law exponents (D) of emphysema hole-size distributions as a competent emphysema index. Robustness to extreme breath-hold-level variations and correlations with clinical parameters for chronic obstructive pulmonary disease (COPD) were investigated and compared to a conventional emphysema index (EI%). PATIENTS AND
methodsA total of 100 patients with COPD (97 males and three females of mean age 67±7.9 years) underwent multidetector row computed tomography scanning at full inspiration and full expiration. The diameters of the emphysematous holes were estimated and quantified with a fully automated algorithm. Power-law exponents (D) of emphysematous hole-size distribution were evaluated.
resultsThe diameters followed a power-law distribution in all cases, suggesting the scale-free nature of emphysema. D of inspiratory and expiratory computed tomography of patients showed intraclass correlation coefficients >0.8, indicating statistically absolute agreement of different breath-hold levels. By contrast, the EI% failed to agree. Bland-Altman analysis also revealed the superior robustness of D to EI%. D also significantly correlated with clinical parameters such as airflow limitation, diffusion capacity, exercise capacity, and quality of life.
conclusionThe D of emphysematous hole-size distribution is robust to breath-hold-level variations and sensitive to the severity of emphysema. This measurement may help rule out the confounding effects of variations in breath-hold levels.
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