ArticleInternational journal of chronic obstructive pulmonary disease2016
Predictors of pneumothorax following endoscopic valve therapy in patients with severe emphysema.
Article in International journal of chronic obstructive pulmonary disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Pooled it
- Expert Statement: Pneumothorax Associated with One-Way Valve Therapy for Emphysema: 2020 Update.Respiration; international review of thoracic diseasesGuideline
- The REACH Trial: A Randomized Controlled Trial Assessing the Safety and Effectiveness of the Spiration® Valve System in the Treatment of Severe Emphysema.Respiration; international review of thoracic diseases · 2019Trial
- Endobronchial Valves for Bronchoscopic Lung Volume Reduction in Severe Emphysema: A Reversible and Non-Surgical Treatment for Patients Who May or May Not Be Candidates for Lung Transplantation.Diagnostics (Basel, Switzerland) · 2026Review
- Risk Factors for Pneumothorax After Treatment With Endobronchial Valves: A Cohort Study.Respirology (Carlton, Vic.) · 2025Article
- Article
- Anesthesia for Bronchoscopy-An Update.Journal of clinical medicine · 2024Review
- First real-time imaging of bronchoscopic lung volume reduction by electrical impedance tomography.Respiratory research · 2024Article
- Surgical and bronchoscopic pulmonary function-improving procedures in lung emphysema.European respiratory review : an official journal of the European Respiratory Society · 2023Review
- Early Spirometry Following Bronchoscopic Lung Volume Reduction with Endobronchial Valves.Journal of clinical medicine · 2022Article
- Long-Term Follow-Up of Intralobar Bullae After Endobronchial Valve Treatment for Emphysema.International journal of chronic obstructive pulmonary disease · 2022Article
- Two-Stage Bronchoscopic Endobronchial Valve Treatment Can Lead to Progressive Lung Volume Reduction and May Decrease Pneumothorax Risk.International journal of chronic obstructive pulmonary disease · 2021Article
- Endobronchial valves for severe emphysema.European respiratory review : an official journal of the European Respiratory Society · 2019Review
- Complications after bronchoscopic lung volume reduction.Journal of thoracic disease · 2018Review
- Clinical and radiological outcome following pneumothorax after endoscopic lung volume reduction with valves.International journal of chronic obstructive pulmonary disease · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndoscopic valve implantation is an effective treatment for patients with advanced emphysema. Despite the minimally invasive procedure, valve placement is associated with risks, the most common of which is pneumothorax. This study was designed to identify predictors of pneumothorax following endoscopic valve implantation.
methodsPreinterventional clinical measures (vital capacity, forced expiratory volume in 1 second, residual volume, total lung capacity, 6-minute walk test), qualitative computed tomography (CT) parameters (fissure integrity, blebs/bulla, subpleural nodules, pleural adhesions, partial atelectasis, fibrotic bands, emphysema type) and quantitative CT parameters (volume and low attenuation volume of the target lobe and the ipsilateral untreated lobe, target air trapping, ipsilateral lobe volume/hemithorax volume, collapsibility of the target lobe and the ipsilateral untreated lobe) were retrospectively evaluated in patients who underwent endoscopic valve placement (n=129). Regression analysis was performed to compare those who developed pneumothorax following valve therapy (n=46) with those who developed target lobe volume reduction without pneumothorax (n=83). FINDING: Low attenuation volume% of ipsilateral untreated lobe (odds ratio [OR] =1.08, P=0.001), ipsilateral untreated lobe volume/hemithorax volume (OR =0.93, P=0.017), emphysema type (OR =0.26, P=0.018), pleural adhesions (OR =0.33, P=0.012) and residual volume (OR =1.58, P=0.012) were found to be significant predictors of pneumothorax. Fissure integrity (OR =1.16, P=0.075) and 6-minute walk test (OR =1.05, P=0.077) were also indicative of pneumothorax. The model including the aforementioned parameters predicted whether a patient would experience a pneumothorax 84% of the time (area under the curve =0.84).
interpretationClinical and CT parameters provide a promising tool to effectively identify patients at high risk of pneumothorax following endoscopic valve therapy.
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