Evidence map›Paper›PMID 27536005›Full record

ArticleNucleic acids research2016

A deafness-associated tRNAAsp mutation alters the m1G37 modification, aminoacylation and stability of tRNAAsp and mitochondrial function.

Meng Wang, Yanyan Peng, Jing Zheng, Binjiao Zheng, Xiaofen Jin, Hao Liu, Yong Wang, Xiaowen Tang, Taosheng Huang, Pingping Jiang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Non-coding RNAs regulating mitochondrial function in cardiovascular diseases.Journal of molecular medicine (Berlin, Germany) · 2023
    Review
  5. Review
  6. Article
  7. Article
  8. Mitochondrial encephalopathy Due to a Novel Pathogenic Mitochondrial tRNAAnnals of clinical and translational neurology · 2020
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Contribution of the tRNAThe Journal of biological chemistry · 2018
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Meng WangDivision of Clinical Genetics and Genomics, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
Yanyan PengInstitute of Genetics, Zhejiang University and Department of Genetics, Zhejiang University, School of Medicine, Hangzhou, Zhejiang 310058, China.
Jing ZhengDivision of Clinical Genetics and Genomics, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
Binjiao ZhengAttardi Institute of Mitochondrial Biomedicine, Wenzhou Medical University, Wenzhou, Zhejiang 325600, China.
Xiaofen JinDivision of Clinical Genetics and Genomics, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
Hao LiuInstitute of Genetics, Zhejiang University and Department of Genetics, Zhejiang University, School of Medicine, Hangzhou, Zhejiang 310058, China.
Yong WangInstitute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Xiaowen TangAttardi Institute of Mitochondrial Biomedicine, Wenzhou Medical University, Wenzhou, Zhejiang 325600, China.
Taosheng HuangDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Pingping JiangDivision of Clinical Genetics and Genomics, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China ppjiang@zju.edu.cn.
Min-Xin GuanDivision of Clinical Genetics and Genomics, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China gminxin88@zju.edu.cn.ORCID 0000-0001-5067-6736
Children's Hospital of Zhejiang University · CNCincinnati Children's Hospital Medical Center · USWenzhou Medical University · CNChinese Academy of Sciences · CNZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this report, we investigated the pathogenic mechanism underlying the deafness-associated mitochondrial(mt) tRNA

Indexed as

Cell LineDeafnessGenetic Association StudiesHumansMaleMembrane Potential, MitochondrialMitochondriaPedigreePoint MutationReactive Oxygen SpeciesRNA StabilityRNA, Transfer, AspYoung AdultReactive Oxygen SpeciesRNA, Transfer, Asp

Identifiers

PMID27536005
PMCPMC5159531
OpenAlexW2514671312

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.