Evidence map›Paper›PMID 27535931›Full record

ArticleGenetics2016

Nationwide Genomic Study in Denmark Reveals Remarkable Population Homogeneity.

Georgios Athanasiadis, Jade Y Cheng, Bjarni J Vilhjálmsson, Frank G Jørgensen, Thomas D Als, Stephanie Le Hellard, Thomas Espeseth, Patrick F Sullivan, Christina M Hultman, Peter C Kjærgaard and 2 more

Abstract read
In one paragraph

Article in Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. Drinking water nitrate and risk of pregnancy loss: a nationwide cohort study.Environmental health : a global access science source · 2022
    Article
  8. Genetic assortative mating for schizophrenia and bipolar disorder.European psychiatry : the journal of the Association of European Psychiatrists · 2022
    Article
  9. The genetic structure of Norway.European journal of human genetics : EJHG · 2021
    Article
  10. Article
  11. Provincial trends in Legionnaires' disease are not explained by population structure in Denmark, 2015 to 2018.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2021
    Article
  12. Article
  13. Article
  14. Sortilin as a Biomarker for Cardiovascular Disease Revisited.Frontiers in cardiovascular medicine · 2021
    Article
  15. Article
  16. Article
  17. Article
  18. Effectiveness of surgery for sciatica with disc herniation is not substantially affected by differences in surgical incidences among three countries: results from the Danish, Swedish and Norwegian spine registries.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2019
    Observational
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Georgios AthanasiadisBioinformatics Research Centre, Aarhus University, 8000, Denmark Centre for Biocultural History, Aarhus University, 8000, Denmark athanasiadis@birc.au.dk.ORCID http://orcid.org/0000-0002-2927-4035
Jade Y ChengBioinformatics Research Centre, Aarhus University, 8000, Denmark.
Bjarni J VilhjálmssonBioinformatics Research Centre, Aarhus University, 8000, Denmark Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts 02115.
Frank G JørgensenTørring Gymnasium, 7160, Denmark.
Thomas D AlsDepartment of Biomedicine, Aarhus University, 8000, Denmark Initiative for Integrative Psychiatric Research, Aarhus University, 8000, Denmark Center for Integrative Sequencing, Aarhus University, 8000, Denmark.
Stephanie Le HellardDr. E. Martens Research Group of Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, 5021, Norway Norwegian Centre for Mental Disorders Research, K. G. Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, 5021, Norway.
Thomas EspesethNorwegian Centre for Mental Disorders Research, K. G. Jebsen Centre for Psychosis Research, Department of Psychology, University of Oslo, 0424, Norway Norwegian Centre for Mental Disorders Research, K. G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, 0424, Norway.
Patrick F SullivanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, 17177, Sweden Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599-7264 Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina 27599-7264.
Christina M HultmanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, 17177, Sweden.
Peter C KjærgaardCentre for Biocultural History, Aarhus University, 8000, Denmark Department of Culture and Society, Aarhus University, 8000, Denmark.
Mikkel H SchierupBioinformatics Research Centre, Aarhus University, 8000, Denmark Centre for Biocultural History, Aarhus University, 8000, Denmark Department of Bioscience, Aarhus University, 8000, Denmark.
Thomas MailundBioinformatics Research Centre, Aarhus University, 8000, Denmark Centre for Biocultural History, Aarhus University, 8000, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Denmark has played a substantial role in the history of Northern Europe. Through a nationwide scientific outreach initiative, we collected genetic and anthropometrical data from ∼800 high school students and used them to elucidate the genetic makeup of the Danish population, as well as to assess polygenic predictions of phenotypic traits in adolescents. We observed remarkable homogeneity across different geographic regions, although we could still detect weak signals of genetic structure reflecting the history of the country. Denmark presented genomic affinity with primarily neighboring countries with overall resemblance of decreasing weight from Britain, Sweden, Norway, Germany, and France. A Polish admixture signal was detected in Zealand and Funen, and our date estimates coincided with historical evidence of Wend settlements in the south of Denmark. We also observed considerably diverse demographic histories among Scandinavian countries, with Denmark having the smallest current effective population size compared to Norway and Sweden. Finally, we found that polygenic prediction of self-reported adolescent height in the population was remarkably accurate (R

Indexed as

DemographyGenetics, PopulationGenomicsAdolescentAnthropometryDenmarkFemaleGenome, HumanHumansMalePopulation Densityadmixturegenetic predictionhuman population geneticspolygenic risk scorepopulation structure

Identifiers

PMID27535931
PMCPMC5068857

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.