Evidence map›Paper›PMID 27535871›Full record

ArticleBrain imaging and behavior2017

Feature fusion via hierarchical supervised local CCA for diagnosis of autism spectrum disorder.

Feng Zhao, Lishan Qiao, Feng Shi, Pew-Thian Yap, Dinggang Shen

Open access · greenAbstract readEvaluation Study
In one paragraph

Article in Brain imaging and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Multiple functional connectivity networks fusion for schizophrenia diagnosis.Medical & biological engineering & computing · 2020
    Article
  7. Article
  8. Article
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Feng ZhaoSchool of Computer Science and Technology, Shandong Institute of Business and Technology, YanTai, China.
Lishan QiaoSchool of Mathematics, Liaocheng University, Liaocheng, China.
Feng ShiDepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, Carolina, North, USA.
Pew-Thian YapDepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, Carolina, North, USA.
Dinggang ShenDepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, Carolina, North, USA. dgshen@med.unc.edu.
University of North Carolina at Chapel Hill · US

Funding

Longitudinal Mapping of Human Brain Development in the First Years of LifeR01EB008374 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAP, PEW-THIAN · 2009 to 2024
$5.1M
Development of Robust Brain Measurement Tools Informed by Ultrahigh Field 7T MRIR01EB006733 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAP, PEW-THIAN · 2008 to 2020
$4.5M
Quantifying Brain Abnormality by Multimodality Neuroimage Analysis,R01AG041721 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, MINGXIA · 2012 to 2019
$3.0M
Fast, Robust Analysis of Large Population DataR01EB009634 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHEN, DINGGANG · 2011 to 2014
$1.3M
4D Cortical Surface Analysis Tools for Study of Early Brain Development in Typical and High-risk InfantsK01MH107815 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, GANG · 2015 to 2018
$559k
National Natural Science Foundation of China 61300154National Natural Science Foundation of China 61373079National Natural Science Foundation of China 61402215NIA NIH HHS R01 AG041721NIBIB NIH HHS R01 EB006733NIBIB NIH HHS R01 EB008374NIBIB NIH HHS R01 EB009634NIH HHS AG041721NIH HHS EB006733NIH HHS EB008374NIH HHS EB009634NIH HHS MH107815NIMH NIH HHS K01 MH107815
6 · The paper itself

Abstract

Early diagnosis of autism spectrum disorder (ASD) is critical for timely medical intervention, for improving patient quality of life, and for reducing the financial burden borne by the society. A key issue in neuroimaging-based ASD diagnosis is the identification of discriminating features and then fusing them to produce accurate diagnosis. In this paper, we propose a novel framework for fusing complementary and discriminating features from different imaging modalities. Specifically, we integrate the Fisher discriminant criterion and local correlation information into the canonical correlation analysis (CCA) framework, giving a new feature fusion method, called Supervised Local CCA (SL-CCA), which caters specifically to local and global multimodal features. To alleviate the neighborhood selection problem associated with SL-CCA, we further propose a hierarchical SL-CCA (HSL-CCA), by performing SL-CCA with the gradually varying neighborhood sizes. Extensive experiments on the multimodal ABIDE database show that the proposed method achieves superior performance. In addition, based on feature weight analysis, we found that only a few specific brain regions play active roles in ASD diagnosis. These brain regions include the putamen, precuneus, and orbitofrontal cortex, which are highly associated with human emotional modulation and memory formation. These finding are consistent with the behavioral phenotype of ASD.

Indexed as

Magnetic Resonance ImagingAutism Spectrum DisorderBrainChildFemaleHumansImage Interpretation, Computer-AssistedMaleAutism spectrum disorder (ASD)Canonical correlation analysis (CCA)Feature fusion

Identifiers

PMID27535871
PMCPMC5315688
OpenAlexW2507492719

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.