Evidence map›Paper›PMID 27535767›Full record

ArticleJournal of child psychology and psychiatry, and allied disciplines2017

Prenatal unhealthy diet, insulin-like growth factor 2 gene (IGF2) methylation, and attention deficit hyperactivity disorder symptoms in youth with early-onset conduct problems.

Jolien Rijlaarsdam, Charlotte A M Cecil, Esther Walton, Maurissa S C Mesirow, Caroline L Relton, Tom R Gaunt, Wendy McArdle, Edward D Barker

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In one paragraph

Article in Journal of child psychology and psychiatry, and allied disciplines, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 5 pooled it
26.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 5 syntheses or guidelines pooled it, 96 citations in OpenAlex.

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  3. Pathogens and global health · 2020
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Jolien RijlaarsdamCentre for Child and Family Studies, Leiden University, Leiden, The Netherlands.
Charlotte A M CecilDepartment of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Esther WaltonDepartment of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Maurissa S C MesirowDepartment of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Caroline L ReltonMedical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Tom R GauntMedical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Wendy McArdleSchool of Social and Community Medicine, University of Bristol, Bristol, UK.
Edward D BarkerDepartment of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
King's College London · GBUniversity of Bristol · GBLeiden University · NLMedical Research Council · GB

Funding

Epigenetic Pathways to Conduct Problem Trajectories: Early Environmental RisksR01HD068437 · NICHD · KING'S COLLEGE LONDON · PI BARKER, EDWARD D., MILL, JONATHAN · 2012 to 2014
$1.1M
Biotechnology and Biological Sciences Research Council BB/I025263/1Biotechnology and Biological Sciences Research Council BBI025751/1Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_UU_12013/2Medical Research Council MC_UU_12013/8NICHD NIH HHS R01 HD068437Wellcome Trust 102215Wellcome Trust 102215/2/13/2
6 · The paper itself

Abstract

backgroundConduct problems (CP) and attention deficit hyperactivity disorder (ADHD) are often comorbid and have each been linked to 'unhealthy diet'. Early-life diet also associates with DNA methylation of the insulin-like growth factor 2 gene (IGF2), involved in fetal and neural development. We investigated the degree to which prenatal high-fat and -sugar diet might relate to ADHD symptoms via IGF2 DNA methylation for early-onset persistent (EOP) versus low CP youth.

methodsParticipants were 164 youth with EOP (n = 83) versus low (n = 81) CP drawn from the Avon Longitudinal Study of Parents and Children. We assessed if the interrelationships between high-fat and -sugar diet (prenatal, postnatal), IGF2 methylation (birth and age 7, collected from blood), and ADHD symptoms (age 7-13) differed for EOP versus low CP youth.

resultsPrenatal 'unhealthy diet' was positively associated with IGF2 methylation at birth for both the EOP and low CP youth. For EOP only: (a) higher IGF2 methylation predicted ADHD symptoms; and (b) prenatal 'unhealthy diet' was associated with higher ADHD symptoms indirectly via higher IGF2 methylation.

conclusionsPreventing 'unhealthy diet' in pregnancy might reduce the risk of ADHD symptoms in EOP youth via lower offspring IGF2 methylation.

Indexed as

Attention Deficit Disorder with HyperactivityChildChild, PreschoolCohort StudiesConduct DisorderDiet, Carbohydrate LoadingDiet, High-FatDNA MethylationEnglandFemaleHumansInfantInfant, NewbornInsulin-Like Growth Factor IIMalePregnancyIGF2 protein, humanInsulin-Like Growth Factor IIattention deficit hyperactivity disorderAvon Longitudinal Study of Parents and Childrenconduct problemsdietDNA methylationIGF2

Identifiers

PMID27535767
PMCPMC5161647
OpenAlexW2513373784

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.