Evidence map›Paper›PMID 27535752›Full record

Trial reportOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2017

Three doses of vitamin D, bone mineral density, and geometry in older women during modest weight control in a 1-year randomized controlled trial.

L C Pop, D Sukumar, S H Schneider, Y Schlussel, T Stahl, C Gordon, X Wang, T V Papathomas, S A Shapses

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01631292 (A Pilot Dose Response Study to Vitamin D in Obesity and Weight Loss), which is not on this map. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01631292 nacompletednot on this map

A Pilot Dose Response Study to Vitamin D in Obesity and Weight Loss: Effect on Bone

TypeinterventionalSponsorRutgers UniversityRan2010 to 2019Enrolled81ConditionsOsteoporosisArms600 IU Vitamin D3, 2000 IU Vitamin D3, 4000 IU Vitamin D3
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  7. Three Doses of Vitamin D and Cognitive Outcomes in Older Women: A Double-Blind Randomized Controlled Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

L C PopDepartment of Nutritional Sciences, Rutgers University, 96 Lipman Drive, New Brunswick, NJ, 08901-8525, USA.
D SukumarDepartment of Nutritional Sciences, Drexel University, Philadelphia, PA, USA.
S H SchneiderDivision of Endocrinology, Metabolism and Nutrition, Department of Medicine, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Y SchlusselDepartment of Nutritional Sciences, Rutgers University, 96 Lipman Drive, New Brunswick, NJ, 08901-8525, USA.
T StahlDepartment of Radiology, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
C GordonDepartment of Radiology, McMaster University, Hamilton, Ontario, Canada.
X WangDivision of Endocrinology, Metabolism and Nutrition, Department of Medicine, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
T V PapathomasDepartment of Biomedical Engineering & Center for Cognitive Science, Rutgers University, New Brunswick, NJ, USA.
S A ShapsesDepartment of Nutritional Sciences, Rutgers University, 96 Lipman Drive, New Brunswick, NJ, 08901-8525, USA. shapses@aesop.rutgers.edu.

Funding

NUTRITIONAL REGULATION OF BONE TURNOVERR01AG012161 · NIA · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI SHAPSES, SUE AMY · 2000 to 2014
$3.4M
NIA NIH HHS R01 AG012161
6 · The paper itself

Abstract

The effects of higher than recommended vitamin D doses on bone mineral density (BMD) and quality are not known. In this study, higher intakes, in postmenopausal women undergoing weight control over 1 year, had no effect on areal or volumetric BMD but prevented the deterioration in cortical bone geometry.

introductionStudies examining how bone responds to a standard dose of vitamin D supplementation have been inconsistent. In addition, the effects of higher doses on BMD and quality are not known. Postmenopausal women undergoing weight control to improve health outcomes are particularly at risk for bone loss and might benefit from supplemental vitamin D intake above the recommended allowance.

methodsThis 1-year-long, randomized, double-blind controlled study addresses whether vitamin D supplementation, in healthy overweight/obese older women, affects BMD and bone structural parameters. In addition, bone turnover and serum total, free, and bioavailable 25-hydroxyvitamin D (25OHD) responses to one of three daily levels of vitamin D

resultsFifty-eight women (age, 58 ± 6 years; body mass index, 30.2 ± 3.8 kg/m

conclusionThe decline in Ct thickness was prevented with higher vitamin D

Indexed as

AgedAnthropometryBody CompositionBody WeightBone DensityBone Density Conservation AgentsCholecalciferolDietary SupplementsDiet, ReducingDose-Response Relationship, DrugDouble-Blind MethodExerciseFemaleHumansMiddle AgedObesityBone Density Conservation AgentsCholecalciferolBody weightCortical thicknessPostmenopausalSerum 25OHDVitamin D

Identifiers

PMID27535752

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.